Now showing items 1-5 of 5

    • Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer. 

      Annibaldi, A; Meier, P (2018-01)
      Tumor necrosis factor (TNF) is a proinflammatory cytokine that coordinates tissue homeostasis by regulating cytokine production, cell survival, and cell death. However, how life and death decisions are made in response to ...
    • Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential. 

      Feltham, R; Jamal, K; Tenev, T; Liccardi, G; Jaco, I; Domingues, CM; Morris, O; John, SW; Annibaldi, A; Widya, M; Kearney, CJ; Clancy, D; Elliott, PR; Glatter, T; Qiao, Q; Thompson, AJ; Nesvizhskii, A; Schmidt, A; Komander, D; Wu, H; Martin, S; Meier, P (2018-04-10)
      Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch between these distinct outcomes remain poorly defined. Here, we show that the E3 ubiquitin ...
    • MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. 

      Jaco, I; Annibaldi, A; Lalaoui, N; Wilson, R; Tenev, T; Laurien, L; Kim, C; Jamal, K; Wicky John, S; Liccardi, G; Chau, D; Murphy, JM; Brumatti, G; Feltham, R; Pasparakis, M; Silke, J; Meier, P (2017-06-01)
      TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α, and its downstream effector kinase ...
    • RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. 

      Liccardi, G; Ramos Garcia, L; Tenev, T; Annibaldi, A; Legrand, AJ; Robertson, D; Feltham, R; Anderton, H; Darding, M; Peltzer, N; Dannappel, M; Schünke, H; Fava, LL; Haschka, MD; Glatter, T; Nesvizhskii, A; Schmidt, A; Harris, PA; Bertin, J; Gough, PJ; Villunger, A; Silke, J; Pasparakis, M; Bianchi, K; Meier, P (2019-02-07)
      Receptor-interacting protein kinase (RIPK) 1 functions as a key mediator of tissue homeostasis via formation of Caspase-8 activating ripoptosome complexes, positively and negatively regulating apoptosis, necroptosis, and ...
    • Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. 

      Annibaldi, A; Wicky John, S; Vanden Berghe, T; Swatek, KN; Ruan, J; Liccardi, G; Bianchi, K; Elliott, PR; Choi, SM; Van Coillie, S; Bertin, J; Wu, H; Komander, D; Vandenabeele, P; Silke, J; Meier, P (2018-02-15)
      Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor κB (NF-κB)-dependent checkpoints suppress the cytotoxic potential of TNF, it remains ...