Now showing items 1-2 of 2

    • Structural basis of RNA polymerase III transcription initiation. 

      Abascal-Palacios, G; Ramsay, EP; Beuron, F; Morris, E; Vannini, A (2018-01-17)
      RNA polymerase (Pol) III transcribes essential non-coding RNAs, including the entire pool of transfer RNAs, the 5S ribosomal RNA and the U6 spliceosomal RNA, and is often deregulated in cancer cells. The initiation of gene ...
    • Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. 

      da Fonseca, PC; Kong, EH; Zhang, Z; Schreiber, A; Williams, MA; Morris, EP; Barford, D (2011-02)
      The ubiquitylation of cell-cycle regulatory proteins by the large multimeric anaphase-promoting complex (APC/C) controls sister chromatid segregation and the exit from mitosis. Selection of APC/C targets is achieved through ...