Now showing items 1-4 of 4

    • Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study. 

      Adams, CD; Richmond, R; Ferreira, DLS; Spiller, W; Tan, V; Zheng, J; Würtz, P; Donovan, J; Hamdy, F; Neal, D; Lane, JA; Smith, GD; Relton, C; Eeles, RA; Haiman, CA; Kote-Jarai, Z; Schumacher, FR; Olama, AAA; Benlloch, S; Muir, K; Berndt, SI; Conti, DV; Wiklund, F; Chanock, SJ; Gapstur, S; Stevens, VL; Tangen, CM; Batra, J; Clements, JA; Gronberg, H; Pashayan, N; Schleutker, J; Albanes, D; Wolk, A; West, CML; Mucci, LA; Cancel-Tassin, G; Koutros, S; Sorensen, KD; Maehle, L; Travis, RC; Hamilton, RJ; Ingles, SA; Rosenstein, BS; Lu, Y-J; Giles, GG; Kibel, AS; Vega, A; Kogevinas, M; Penney, KL; Park, JY; Stanford, JL; Cybulski, C; Nordestgaard, BG; Brenner, H; Maier, C; Kim, J; John, EM; Teixeira, MR; Neuhausen, SL; De Ruyck, K; Razack, A; Newcomb, LF; Lessel, D; Kaneva, RP; Usmani, N; Claessens, F; Townsend, PA; Dominguez, MG; Roobol, MJ; Menegaux, F; Khaw, K-T; Cannon-Albright, LA; Pandha, H; Thibodeau, SN; Martin, RM; PRACTICAL consortium (2019-01)
      BACKGROUND:Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise ...
    • Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer. 

      Rodriguez-Broadbent, H; Law, PJ; Sud, A; Palin, K; Tuupanen, S; Gylfe, A; Hänninen, UA; Cajuso, T; Tanskanen, T; Kondelin, J; Kaasinen, E; Sarin, A-P; Ripatti, S; Eriksson, JG; Rissanen, H; Knekt, P; Pukkala, E; Jousilahti, P; Salomaa, V; Palotie, A; Renkonen-Sinisalo, L; Lepistö, A; Böhm, J; Mecklin, J-P; Al-Tassan, NA; Palles, C; Martin, L; Barclay, E; Farrington, SM; Timofeeva, MN; Meyer, BF; Wakil, SM; Campbell, H; Smith, CG; Idziaszczyk, S; Maughan, TS; Kaplan, R; Kerr, R; Kerr, D; Passarelli, MN; Figueiredo, JC; Buchanan, DD; Win, AK; Hopper, JL; Jenkins, MA; Lindor, NM; Newcomb, PA; Gallinger, S; Conti, D; Schumacher, F; Casey, G; Aaltonen, LA; Cheadle, JP; Tomlinson, IP; Dunlop, MG; Houlston, RS (2017-06)
      While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to examine the ...
    • A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife. 

      Alexander, J; Gildea, L; Balog, J; Speller, A; McKenzie, J; Muirhead, L; Scott, A; Kontovounisios, C; Rasheed, S; Teare, J; Hoare, J; Veselkov, K; Goldin, R; Tekkis, P; Darzi, A; Nicholson, J; Kinross, J; Takats, Z (2017-03)
      This pilot study assessed the diagnostic accuracy of rapid evaporative ionization mass spectrometry (REIMS) in colorectal cancer (CRC) and colonic adenomas.Patients undergoing elective surgical resection for CRC were ...
    • Pleiotropic Analysis of Lung Cancer and Blood Triglycerides. 

      Zuber, V; Marconett, CN; Shi, J; Hua, X; Wheeler, W; Yang, C; Song, L; Dale, AM; Laplana, M; Risch, A; Witoelar, A; Thompson, WK; Schork, AJ; Bettella, F; Wang, Y; Djurovic, S; Zhou, B; Borok, Z; van der Heijden, HFM; de Graaf, J; Swinkels, D; Aben, KK; McKay, J; Hung, RJ; Bikeböller, H; Stevens, VL; Albanes, D; Caporaso, NE; Han, Y; Wei, Y; Panadero, MA; Mayordomo, JI; Christiani, DC; Kiemeney, L; Andreassen, OA; Houlston, R; Amos, CI; Chatterjee, N; Laird-Offringa, IA; Mills, IG; Landi, MT (2016-12)
      Epidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted ...