Now showing items 1-20 of 20

    • Advances in mass spectrometry based strategies to study receptor tyrosine kinases. 

      Vyse, S; Desmond, H; Huang, PH (2017-03-01)
      Receptor tyrosine kinases (RTKs) are key transmembrane environmental sensors that are capable of transmitting extracellular information into phenotypic responses, including cell proliferation, survival and metabolism. ...
    • Can Interrogation of Tumour Characteristics Lead us to Safely Omit Adjuvant Radiotherapy in Patients with Early Breast Cancer? 

      Bhattacharya, IS; Kirby, AM; Bliss, JM; Coles, CE (2018-03)
      Adjuvant radiotherapy after breast-conserving surgery has been an important component of the standard of care for early breast cancer. Improvements in breast cancer care have resulted in a substantial reduction in local ...
    • CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer. 

      Bridgett, S; Campbell, J; Lord, CJ; Ryan, CJ (2017-07-26)
      Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that ...
    • CanVar: A resource for sharing germline variation in cancer patients. 

      Chubb, D; Broderick, P; Dobbins, SE; Houlston, RS (2016)
      The advent of high-throughput sequencing has accelerated our ability to discover genes predisposing to disease and is transforming clinical genomic sequencing. In both contexts knowledge of the spectrum and frequency of ...
    • Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects. 

      Brody, LP; Sahuri-Arisoylu, M; Parkinson, JR; Parkes, HG; So, PW; Hajji, N; Thomas, EL; Frost, GS; Miller, AD; Bell, JD (2017)
      Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a ...
    • Combined linkage and association analysis of classical Hodgkin lymphoma. 

      Lawrie, A; Han, S; Sud, A; Hosking, F; Cezard, T; Turner, D; Clark, C; Murray, GI; Culligan, DJ; Houlston, RS; Vickers, MA (2018-04-17)
      The heritability of classical Hodgkin lymphoma (cHL) has yet to be fully deciphered. We report a family with five members diagnosed with nodular sclerosis cHL. Genetic analysis of the family provided evidence of linkage ...
    • Combining radiation with hyperthermia: a multiscale model informed by in vitro experiments. 

      Brüningk, S; Powathil, G; Ziegenhein, P; Ijaz, J; Rivens, I; Nill, S; Chaplain, M; Oelfke, U; Ter Haar, G (2018-01)
      Combined radiotherapy and hyperthermia offer great potential for the successful treatment of radio-resistant tumours through thermo-radiosensitization. Tumour response heterogeneity, due to intrinsic, or micro-environmentally ...
    • A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events. 

      Ryan, CJ; Kennedy, S; Bajrami, I; Matallanas, D; Lord, CJ (2017-10-25)
      Protein complexes are responsible for the bulk of activities within the cell, but how their behavior and abundance varies across tumors remains poorly understood. By combining proteomic profiles of breast tumors with a ...
    • DNA Damage, Repair, and Cancer Metabolism. 

      Turgeon, M-O; Perry, NJS; Poulogiannis, G (2018)
      Although there has been a renewed interest in the field of cancer metabolism in the last decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be appreciably explored. In this review, we examine ...
    • Empowerment in adolescents and young adults with cancer: Relationship with health-related quality of life. 

      Kaal, SEJ; Husson, O; van Duivenboden, S; Jansen, R; Manten-Horst, E; Servaes, P; Prins, JB; van den Berg, SW; van der Graaf, WTA (2017-10-15)
      BACKGROUND: The difficulties adolescents and young adults (AYAs) encounter during a cancer experience may result in a reduction in or absence of empowerment. The aims of the current study were to assess levels of empowerment ...
    • Health economic impact of liquid biopsies in cancer management. 

      IJzerman, MJ; Berghuis, AMS; de Bono, JS; Terstappen, LWMM (2018-12)
      INTRODUCTION: Liquid biopsies (LBs) are referred to as the sampling and analysis of non-solid tissue, primarily blood, as a diagnostic and monitoring tool for cancer. Because LBs are largely non-invasive, they are a ...
    • Molecularly targeted therapies in cancer: a guide for the nuclear medicine physician. 

      Lheureux, S; Denoyelle, C; Ohashi, PS; De Bono, JS; Mottaghy, FM (2017-08)
      Molecular imaging continues to influence every aspect of cancer care including detection, diagnosis, staging and therapy response assessment. Recent advances in the understanding of cancer biology have prompted the ...
    • Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer. 

      Koundouros, N; Poulogiannis, G (2018)
      Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant regulation of oncogenic signaling cascades ...
    • The PI3K Pathway at the Crossroads of Cancer and the Immune System: Strategies for Next Generation Immunotherapy Combinations. 

      Collins, DC; Chenard-Poirier, M; Lopez, JS (2018)
      Immunotherapy has led to a paradigm shift in the treatment of some malignancies, providing long-term, durable responses for a subset of patients with advanced cancers. Increasingly, research has identified links between ...
    • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes. 

      Mavaddat, N; Michailidou, K; Dennis, J; Lush, M; Fachal, L; Lee, A; Tyrer, JP; Chen, T-H; Wang, Q; Bolla, MK; Yang, X; Adank, MA; Ahearn, T; Aittomäki, K; Allen, J; Andrulis, IL; Anton-Culver, H; Antonenkova, NN; Arndt, V; Aronson, KJ; Auer, PL; Auvinen, P; Barrdahl, M; Beane Freeman, LE; Beckmann, MW; Behrens, S; Benitez, J; Bermisheva, M; Bernstein, L; Blomqvist, C; Bogdanova, NV; Bojesen, SE; Bonanni, B; Børresen-Dale, A-L; Brauch, H; Bremer, M; Brenner, H; Brentnall, A; Brock, IW; Brooks-Wilson, A; Brucker, SY; Brüning, T; Burwinkel, B; Campa, D; Carter, BD; Castelao, JE; Chanock, SJ; Chlebowski, R; Christiansen, H; Clarke, CL; Collée, JM; Cordina-Duverger, E; Cornelissen, S; Couch, FJ; Cox, A; Cross, SS; Czene, K; Daly, MB; Devilee, P; Dörk, T; Dos-Santos-Silva, I; Dumont, M; Durcan, L; Dwek, M; Eccles, DM; Ekici, AB; Eliassen, AH; Ellberg, C; Engel, C; Eriksson, M; Evans, DG; Fasching, PA; Figueroa, J; Fletcher, O; Flyger, H; Försti, A; Fritschi, L; Gabrielson, M; Gago-Dominguez, M; Gapstur, SM; García-Sáenz, JA; Gaudet, MM; Georgoulias, V; Giles, GG; Gilyazova, IR; Glendon, G; Goldberg, MS; Goldgar, DE; González-Neira, A; Grenaker Alnæs, GI; Grip, M; Gronwald, J; Grundy, A; Guénel, P; Haeberle, L; Hahnen, E; Haiman, CA; Håkansson, N; Hamann, U; Hankinson, SE; Harkness, EF; Hart, SN; He, W; Hein, A; Heyworth, J; Hillemanns, P; Hollestelle, A; Hooning, MJ; Hoover, RN; Hopper, JL; Howell, A; Huang, G; Humphreys, K; Hunter, DJ; Jakimovska, M; Jakubowska, A; Janni, W; John, EM; Johnson, N; Jones, ME; Jukkola-Vuorinen, A; Jung, A; Kaaks, R; Kaczmarek, K; Kataja, V; Keeman, R; Kerin, MJ; Khusnutdinova, E; Kiiski, JI; Knight, JA; Ko, Y-D; Kosma, V-M; Koutros, S; Kristensen, VN; Krüger, U; Kühl, T; Lambrechts, D; Le Marchand, L; Lee, E; Lejbkowicz, F; Lilyquist, J; Lindblom, A; Lindström, S; Lissowska, J; Lo, W-Y; Loibl, S; Long, J; Lubiński, J; Lux, MP; MacInnis, RJ; Maishman, T; Makalic, E; Maleva Kostovska, I; Mannermaa, A; Manoukian, S; Margolin, S; Martens, JWM; Martinez, ME; Mavroudis, D; McLean, C; Meindl, A; Menon, U; Middha, P; Miller, N; Moreno, F; Mulligan, AM; Mulot, C; Muñoz-Garzon, VM; Neuhausen, SL; Nevanlinna, H; Neven, P; Newman, WG; Nielsen, SF; Nordestgaard, BG; Norman, A; Offit, K; Olson, JE; Olsson, H; Orr, N; Pankratz, VS; Park-Simon, T-W; Perez, JIA; Pérez-Barrios, C; Peterlongo, P; Peto, J; Pinchev, M; Plaseska-Karanfilska, D; Polley, EC; Prentice, R; Presneau, N; Prokofyeva, D; Purrington, K; Pylkäs, K; Rack, B; Radice, P; Rau-Murthy, R; Rennert, G; Rennert, HS; Rhenius, V; Robson, M; Romero, A; Ruddy, KJ; Ruebner, M; Saloustros, E; Sandler, DP; Sawyer, EJ; Schmidt, DF; Schmutzler, RK; Schneeweiss, A; Schoemaker, MJ; Schumacher, F; Schürmann, P; Schwentner, L; Scott, C; Scott, RJ; Seynaeve, C; Shah, M; Sherman, ME; Shrubsole, MJ; Shu, X-O; Slager, S; Smeets, A; Sohn, C; Soucy, P; Southey, MC; Spinelli, JJ; Stegmaier, C; Stone, J; Swerdlow, AJ; Tamimi, RM; Tapper, WJ; Taylor, JA; Terry, MB; Thöne, K; Tollenaar, RAEM; Tomlinson, I; Truong, T; Tzardi, M; Ulmer, H-U; Untch, M; Vachon, CM; van Veen, EM; Vijai, J; Weinberg, CR; Wendt, C; Whittemore, AS; Wildiers, H; Willett, W; Winqvist, R; Wolk, A; Yang, XR; Yannoukakos, D; Zhang, Y; Zheng, W; Ziogas, A; ABCTB Investigators; kConFab/AOCS Investigators; NBCS Collaborators; Dunning, AM; Thompson, DJ; Chenevix-Trench, G; Chang-Claude, J; Schmidt, MK; Hall, P; Milne, RL; Pharoah, PDP; Antoniou, AC; Chatterjee, N; Kraft, P; García-Closas, M; Simard, J; Easton, DF (2019-01-03)
      Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen ...
    • Randomized controlled trial of dietary fiber for the prevention of radiation-induced gastrointestinal toxicity during pelvic radiotherapy. 

      Wedlake, L; Shaw, C; McNair, H; Lalji, A; Mohammed, K; Klopper, T; Allan, L; Tait, D; Hawkins, M; Somaiah, N; Lalondrelle, S; Taylor, A; VanAs, N; Stewart, A; Essapen, S; Gage, H; Whelan, K; Andreyev, HJN (2017-09)
      Background: Therapeutic radiotherapy is an important treatment of pelvic cancers. Historically, low-fiber diets have been recommended despite a lack of evidence and potentially beneficial mechanisms of fiber.Objective: ...
    • Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. 

      Meisenberg, C; Pinder, SI; Hopkins, SR; Wooller, SK; Benstead-Hume, G; Pearl, FMG; Jeggo, PA; Downs, JA (2019-01-17)
      Cohesin subunits are frequently mutated in cancer, but how they function as tumor suppressors is unknown. Cohesin mediates sister chromatid cohesion, but this is not always perturbed in cancer cells. Here, we identify a ...
    • RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. 

      Liccardi, G; Ramos Garcia, L; Tenev, T; Annibaldi, A; Legrand, AJ; Robertson, D; Feltham, R; Anderton, H; Darding, M; Peltzer, N; Dannappel, M; Schünke, H; Fava, LL; Haschka, MD; Glatter, T; Nesvizhskii, A; Schmidt, A; Harris, PA; Bertin, J; Gough, PJ; Villunger, A; Silke, J; Pasparakis, M; Bianchi, K; Meier, P (2019-02-07)
      Receptor-interacting protein kinase (RIPK) 1 functions as a key mediator of tissue homeostasis via formation of Caspase-8 activating ripoptosome complexes, positively and negatively regulating apoptosis, necroptosis, and ...
    • The Role of PI3K in Met Driven Cancer: A Recap. 

      Hervieu, A; Kermorgant, S (2018)
      The Receptor Tyrosine Kinase (RTK) Met, overexpressed or mutated in cancer, plays a major role in cancer progression and represents an attractive target for cancer therapy. However RTK inhibitors can lead to drug resistance, ...
    • Symptom Burden in Advanced Soft-Tissue Sarcoma. 

      Gough, N; Koffman, J; Ross, JR; Riley, J; Judson, I (2017-03)
      CONTEXT: There is little information on symptom prevalence and severity in advanced soft-tissue sarcoma (STS). Understanding symptom burden will aid clinical consultations, clarify which symptom interventions are needed, ...