Now showing items 1-2 of 2

    • Embryonic transcription factor SOX9 drives breast cancer endocrine resistance. 

      Jeselsohn, R; Cornwell, M; Pun, M; Buchwalter, G; Nguyen, M; Bango, C; Huang, Y; Kuang, Y; Paweletz, C; Fu, X; Nardone, A; De Angelis, C; Detre, S; Dodson, A; Mohammed, H; Carroll, JS; Bowden, M; Rao, P; Long, HW; Li, F; Dowsett, M; Schiff, R; Brown, M (2017-05-30)
      The estrogen receptor (ER) drives the growth of most luminal breast cancers and is the primary target of endocrine therapy. Although ER blockade with drugs such as tamoxifen is very effective, a major clinical limitation ...
    • Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. 

      Xiao, T; Li, W; Wang, X; Xu, H; Yang, J; Wu, Q; Huang, Y; Geradts, J; Jiang, P; Fei, T; Chi, D; Zang, C; Liao, Q; Rennhack, J; Andrechek, E; Li, N; Detre, S; Dowsett, M; Jeselsohn, RM; Liu, XS; Brown, M (2018-07-31)
      Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER+) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical ...