Browsing ICR Divisions by author "Atrash, Butrus"
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Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design
Bavetsias, V; Blagg, J; Bayliss, R (2010)The production of selective protein kinase inhibitors is often frustrated by the similarity of the enzyme active sites. For this reason, it is challenging to design inhibitors that discriminate between the three Aurora ...