Now showing items 1-3 of 3

    • The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase 

      Cox, TR; Rumney, RMH; Schoof, EM; Perryman, L; Hoye, AM; Agrawal, A; Bird, D; Ab Latif, N; Forrest, H; Evans, HR; Huggins, ID; Lang, G; Linding, R; Gartland, A; Erler, JT (NATURE PUBLISHING GROUP, 2015-06-04)
      Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia(1). ...
    • LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis 

      Cox, TR; Bird, D; Baker, A-M; Barker, HE; Ho, MW-Y; Lang, G; Erler, JT (AMER ASSOC CANCER RESEARCH, 2013-03-15)
      Tumor metastasis is a highly complex, dynamic, and inefficient process involving multiple steps, yet it accounts for more than 90% of cancer-related deaths. Although it has long been known that fibrotic signals enhance ...
    • The rationale for targeting the LOX family in cancer 

      Barker, HE; Cox, TR; Erler, JT (NATURE PUBLISHING GROUP, 2012-08)
      The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of evidence implicating the tumour microenvironment as pivotal in all aspects of tumour initiation and progression. Members of the ...