Now showing items 1-3 of 3

    • The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase 

      Cox, TR; Rumney, RMH; Schoof, EM; Perryman, L; Hoye, AM; Agrawal, A; Bird, D; Ab Latif, N; Forrest, H; Evans, HR; Huggins, ID; Lang, G; Linding, R; Gartland, A; Erler, JT (NATURE PUBLISHING GROUP, 2015-06-04)
      Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia(1). ...
    • LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis 

      Cox, TR; Bird, D; Baker, A-M; Barker, HE; Ho, MW-Y; Lang, G; Erler, JT (AMER ASSOC CANCER RESEARCH, 2013-03-15)
      Tumor metastasis is a highly complex, dynamic, and inefficient process involving multiple steps, yet it accounts for more than 90% of cancer-related deaths. Although it has long been known that fibrotic signals enhance ...
    • Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling 

      Barker, HE; Bird, D; Lang, G; Erler, JT (AMER ASSOC CANCER RESEARCH, 2013-11)
      Cancer-associated fibroblasts enhance cancer progression when activated by tumor cells through mechanisms not yet fully understood. Blocking mammary tumor cell-derived lysyl oxidase-like 2 (LOXL2) significantly inhibited ...