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    • Frat is dispensable for canonical Wnt signaling in mammals 

      van Amerongen, R; Nawijn, M; Franca-Koh, J; Zevenhoven, J; van der Gulden, H; Jonkers, J; Berns, A (2005-02-15)
      Wnt-signal transduction through beta-catenin is thought to require the inhibition of GSK3 by Frat/GBP. To investigate the role of Frat in mammalian development, we have generated mice with targeted mutations in all three ...