Browsing ICR Divisions by title
Now showing items 2006-2025 of 5463
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Folate Receptor beta as a Potential Delivery Route for Novel Folate Antagonists to Macrophages in the Synovial Tissue of Rheumatoid Arthritis Patients
(WILEY, 2009-01)Objective. To determine the expression of folate receptor beta (FR beta) in synovial biopsy tissues and peripheral blood lymphocytes from rheumatoid arthritis (RA) patients and to identify novel folate antagonists that are ... -
Follicular thyroid carcinoma presenting with pathological fracture of the humerus at initial diagnosis
(Oxford University Press (OUP), 2017-01-01) -
Follow-up after treatment for head and neck cancer: United Kingdom National Multidisciplinary Guidelines.
This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. In the absence of high-level evidence base for follow-up practices, the duration and ... -
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
(2012-06)Inhibition of the protein kinase WEE1 synergizes with chemotherapy in preclinical models and WEE1 inhibitors are being explored as potential cancer therapies. Here, we investigate the mechanism that underlies this synergy. ... -
Forward- and Inverse-Planned Intensity-Modulated Radiotherapy in the CHHiP Trial: A Comparison of Dosimetry and Normal Tissue Toxicity.
(2019-09)Aims The CHHiP (Conventional or Hypofractionated High-dose Intensity Modulated Radiotherapy In Prostate Cancer; CRUK/06/016) trial investigated hypofractionated radiotherapy for localised prostate cancer. Forward- (FP) or ... -
Four-dimensional imaging for radiotherapy planning in children and teenagers
(Institute of Cancer Research (University Of London), 2021-02-28)Respiratory-related organ motion (RROM) is a potential source of geometric uncertainty in RT planning and delivery. Approaches to mitigate its effects are well described in adults. For example, four-dimensional computed ... -
Fractionated stereotactic conformal radiotherapy for secreting and nonsecreting pituitary adenomas
(BLACKWELL PUBLISHING, 2006-05)Objective To assess the medium-term outcome in a cohort of patients with residual or recurrent pituitary adenoma treated with fractionated stereotactic conformal radiotherapy (SCRT). Patients and methods Ninety-two patients ... -
FRACTIONATED STEREOTACTIC RADIOTHERAPY IN THE TREATMENT OF VESTIBULAR SCHWANNOMA (ACOUSTIC NEUROMA): PREDICTING THE RISK OF HYDROCEPHALUS
(ELSEVIER SCIENCE INC, 2011-07-15)Purpose: To determine the incidence and predictive factors for the development of hydrocephalus in patients with acoustic neuromas (AN) treated with fractionated stereotactic radiotherapy. Patients and Methods: Seventy-two ... -
Fractionation Choice for Elective Lymph Node Radiation Therapy in Prostate Cancer: Slightly More to CHIRP About.
(Elsevier BV, 2022-07-14) -
Fractionation Choice for Elective Lymph Node Radiation Therapy in Prostate Cancer: Slightly More to CHIRP About.
(Elsevier BV, 2022-07-14) -
Fragment growing to retain or alter the selectivity of anchored kinase hinge-binding fragments
(ROYAL SOC CHEMISTRY, 2014-01-01) -
Fragment-based discovery of HSP70 inhibitors
(Institute of Cancer Research (University Of London), 2021-01-31)Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and are often associated with metastasis and poor prognosis. Dual silencing of two isoforms, HSP72 and HSC70, using siRNA ... -
Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.
(2019-12-13)The PARP enzyme and scaffolding protein tankyrase (TNKS, TNKS2) uses its ankyrin repeat clusters (ARCs) to bind a wide range of proteins and thereby controls diverse cellular functions. A number of these are implicated in ... -
Frailty in Very Elderly Patients is Not Associated with Adverse Surgical or Oncological Outcomes in Extremity Surgery for Soft Tissue Sarcoma.
(2022-02-03)<h4>Background</h4>While surgery remains the mainstay of treatment for limb sarcoma, extreme old age is a relative contraindication to oncological surgery.<h4>Methods</h4>Patients >80 years referred with primary extremity ... -
Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III trial.
(BMJ PUBLISHING GROUP, 2022-06-02)INTRODUCTION: Multiple myeloma is a bone marrow cancer, which predominantly affects older people. The incidence is increasing in an ageing population.Over the last 10 years, patient outcomes have improved. However, this ... -
Frat is dispensable for canonical Wnt signaling in mammals
(2005-02-15)Wnt-signal transduction through beta-catenin is thought to require the inhibition of GSK3 by Frat/GBP. To investigate the role of Frat in mammalian development, we have generated mice with targeted mutations in all three ... -
Free-View, 3D Gaze-Guided, Assistive Robotic System for Activities of Daily Living
(IEEE, 2018-01-01) -
Frequency and Prognostic Impact of <i>ALK</i> Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1).
(2021-06-11)Purpose In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated through activating point mutations or genomic amplification. We studied ALK genetic alterations in high-risk (HR) patients on ...
