Now showing items 1-8 of 8

    • ChEMBL: a large-scale bioactivity database for drug discovery. 

      Gaulton, A; Bellis, LJ; Bento, AP; Chambers, J; Davies, M; Hersey, A; Light, Y; McGlinchey, S; Michalovich, D; Al-Lazikani, B; Overington, JP (2012-01)
      ChEMBL is an Open Data database containing binding, functional and ADMET information for a large number of drug-like bioactive compounds. These data are manually abstracted from the primary published literature on a regular ...
    • ELM-the eukaryotic linear motif resource in 2020. 

      Kumar, M; Kumar, M; Gouw, M; Michael, S; Sámano-Sánchez, H; Pancsa, R; Glavina, J; Diakogianni, A; Valverde, JA; Bukirova, D; Čalyševa, J; Palopoli, N; Davey, NE; Chemes, LB; Gibson, TJ (2020-01)
      The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource ...
    • ELM: the status of the 2010 eukaryotic linear motif resource. 

      Gould, CM; Diella, F; Via, A; Puntervoll, P; Gemünd, C; Chabanis-Davidson, S; Michael, S; Sayadi, A; Bryne, JC; Chica, C; Seiler, M; Davey, NE; Haslam, N; Weatheritt, RJ; Budd, A; Hughes, T; Pas, J; Rychlewski, L; Travé, G; Aasland, R; Helmer-Citterich, M; Linding, R; Gibson, TJ (2010-01)
      Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through protein modifications at linear motifs. ...
    • MobiDB: intrinsically disordered proteins in 2021. 

      Piovesan, D; Necci, M; Escobedo, N; Monzon, AM; Hatos, A; Mičetić, I; Quaglia, F; Paladin, L; Ramasamy, P; Dosztányi, Z; Vranken, WF; Davey, NE; Parisi, G; Fuxreiter, M; Tosatto, SCE
      The MobiDB database (URL: https://mobidb.org/) provides predictions and annotations for intrinsically disordered proteins. Here, we report recent developments implemented in MobiDB version 4, regarding the database format, ...
    • MoKCa database--mutations of kinases in cancer. 

      Richardson, CJ; Gao, Q; Mitsopoulous, C; Zvelebil, M; Pearl, LH; Pearl, FMG (2009-01)
      Members of the protein kinase family are amongst the most commonly mutated genes in human cancer, and both mutated and activated protein kinases have proved to be tractable targets for the development of new anticancer ...
    • PDBe-KB: a community-driven resource for structural and functional annotations. 

      PDBe-KB consortium (2020-01)
      The Protein Data Bank in Europe-Knowledge Base (PDBe-KB, https://pdbe-kb.org) is a community-driven, collaborative resource for literature-derived, manually curated and computationally predicted structural and functional ...
    • Structure-based drug design: aiming for a perfect fit. 

      van Montfort, RLM; Workman, P (2017-11-08)
      Knowledge of the three-dimensional structure of therapeutically relevant targets has informed drug discovery since the first protein structures were determined using X-ray crystallography in the 1950s and 1960s. In this ...
    • Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis. 

      Evans, IM; Kennedy, SA; Paliashvili, K; Santra, T; Yamaji, M; Lovering, RC; Britton, G; Frankel, P; Kolch, W; Zachary, IC (2017-02)
      p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells ...