Now showing items 1-7 of 7

    • AMPK-independent inhibition of human macrophage ER stress response by AICAR. 

      Boß, M; Newbatt, Y; Gupta, S; Collins, I; Brüne, B; Namgaladze, D (2016-08-26)
      Obesity-associated insulin resistance is driven by inflammatory processes in response to metabolic overload. Obesity-associated inflammation can be recapitulated in cell culture by exposing macrophages to saturated fatty ...
    • Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity. 

      Thomas, DC; Clare, S; Sowerby, JM; Pardo, M; Juss, JK; Goulding, DA; van der Weyden, L; Storisteanu, D; Prakash, A; Espéli, M; Flint, S; Lee, JC; Hoenderdos, K; Kane, L; Harcourt, K; Mukhopadhyay, S; Umrania, Y; Antrobus, R; Nathan, JA; Adams, DJ; Bateman, A; Choudhary, JS; Lyons, PA; Condliffe, AM; Chilvers, ER; Dougan, G; Smith, KGC (2017-04)
      The phagocyte respiratory burst is crucial for innate immunity. The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising gp91phox and p22phox subunits. Deficiency of either subunit leads ...
    • Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis. 

      Yeung, ATY; Hale, C; Lee, AH; Gill, EE; Bushell, W; Parry-Smith, D; Goulding, D; Pickard, D; Roumeliotis, T; Choudhary, J; Thomson, N; Skarnes, WC; Dougan, G; Hancock, REW (2017-04-25)
      Chlamydia trachomatis remains a leading cause of bacterial sexually transmitted infections and preventable blindness worldwide. There are, however, limited in vitro models to study the role of host genetics in the response ...
    • Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer. 

      Evans, R; Flores-Borja, F; Nassiri, S; Miranda, E; Lawler, K; Grigoriadis, A; Monypenny, J; Gillet, C; Owen, J; Gordon, P; Male, V; Cheung, A; Noor, F; Barber, P; Marlow, R; Francesch-Domenech, E; Fruhwirth, G; Squadrito, M; Vojnovic, B; Tutt, A; Festy, F; De Palma, M; Ng, T (2019-05)
      Lymphatic vasculature is crucial for metastasis in triple-negative breast cancer (TNBC); however, cellular and molecular drivers controlling lymphovascular metastasis are poorly understood. We define a macrophage-dependent ...
    • Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma. 

      Fultang, L; Gamble, LD; Gneo, L; Berry, AM; Egan, SA; De Bie, F; Yogev, O; Eden, GL; Booth, S; Brownhill, S; Vardon, A; McConville, CM; Cheng, PN; Norris, MD; Etchevers, HC; Murray, J; Ziegler, DS; Chesler, L; Schmidt, R; Burchill, SA; Haber, M; De Santo, C; Mussai, F (2019-02)
      Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine ...
    • Pan-cancer deconvolution of tumour composition using DNA methylation. 

      Chakravarthy, A; Furness, A; Joshi, K; Ghorani, E; Ford, K; Ward, MJ; King, EV; Lechner, M; Marafioti, T; Quezada, SA; Thomas, GJ; Feber, A; Fenton, TR (2018-08-13)
      The nature and extent of immune cell infiltration into solid tumours are key determinants of therapeutic response. Here, using a DNA methylation-based approach to tumour cell fraction deconvolution, we report the integrated ...
    • Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1. 

      Roux, C; Jafari, SM; Shinde, R; Duncan, G; Cescon, DW; Silvester, J; Chu, MF; Hodgson, K; Berger, T; Wakeham, A; Palomero, L; Garcia-Valero, M; Pujana, MA; Mak, TW; McGaha, TL; Cappello, P; Gorrini, C (2019-03)
      The combination of immune checkpoint blockade with chemotherapy is currently under investigation as a promising strategy for the treatment of triple negative breast cancer (TNBC). Tumor-associated macrophages (TAMs) are ...