Now showing items 1-3 of 3

    • Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer. 

      Brough, R; Gulati, A; Haider, S; Kumar, R; Campbell, J; Knudsen, E; Pettitt, SJ; Ryan, CJ; Lord, CJ (2018-10)
      Although defects in the RB1 tumour suppressor are one of the more common driver alterations found in triple-negative breast cancer (TNBC), therapeutic approaches that exploit this have not been identified. By integrating ...
    • Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13. 

      Alfieri, C; Chang, L; Barford, D (2018-07-04)
      The maintenance of genome stability during mitosis is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex (MCC), an inhibitor of the anaphase-promoting complex (APC/C, ...
    • Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells. 

      Dev, H; Chiang, T-WW; Lescale, C; de Krijger, I; Martin, AG; Pilger, D; Coates, J; Sczaniecka-Clift, M; Wei, W; Ostermaier, M; Herzog, M; Lam, J; Shea, A; Demir, M; Wu, Q; Yang, F; Fu, B; Lai, Z; Balmus, G; Belotserkovskaya, R; Serra, V; O'Connor, MJ; Bruna, A; Beli, P; Pellegrini, L; Caldas, C; Deriano, L; Jacobs, JJL; Galanty, Y; Jackson, SP (2018-08)
      BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To understand the resistance mechanisms, we conducted whole-genome ...