Now showing items 1-2 of 2

    • Novel insights into mesothelioma biology and implications for therapy. 

      Yap, TA; Aerts, JG; Popat, S; Fennell, DA (2017-07)
      Malignant mesothelioma is a universally lethal cancer that is increasing in incidence worldwide. There is a dearth of effective therapies, with only one treatment (pemetrexed and cisplatin combination chemotherapy) approved ...
    • The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer. 

      Khan, OM; Carvalho, J; Spencer-Dene, B; Mitter, R; Frith, D; Snijders, AP; Wood, SA; Behrens, A (2018-04)
      The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in several human cancers. We noted that in a substantial percentage of colon cancers, FBW7 protein is undetectable despite the ...