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    • The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation. 

      Parzych, K; Saavedra-García, P; Valbuena, GN; Al-Sadah, HA; Robinson, ME; Penfold, L; Kuzeva, DM; Ruiz-Tellez, A; Loaiza, S; Holzmann, V; Caputo, V; Johnson, DC; Kaiser, MF; Karadimitris, A; Lam, EW-F; Chevet, E; Feldhahn, N; Keun, HC; Auner, HW (2019-04)
      VCP/p97 regulates numerous cellular functions by mediating protein degradation through its segregase activity. Its key role in governing protein homoeostasis has made VCP/p97 an appealing anticancer drug target. Here, we ...