Now showing items 1-7 of 7

    • Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors. 

      Arce Vargas, F; Furness, AJS; Solomon, I; Joshi, K; Mekkaoui, L; Lesko, MH; Miranda Rota, E; Dahan, R; Georgiou, A; Sledzinska, A; Ben Aissa, A; Franz, D; Werner Sunderland, M; Wong, YNS; Henry, JY; O'Brien, T; Nicol, D; Challacombe, B; Beers, SA; Melanoma TRACERx Consortium; Renal TRACERx Consortium; Lung TRACERx Consortium; Turajlic, S; Gore, M; Larkin, J; Swanton, C; Chester, KA; Pule, M; Ravetch, JV; Marafioti, T; Peggs, KS; Quezada, SA (2017-04-11)
      CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We ...
    • Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway. 

      Conti, A; Majorini, MT; Elliott, R; Ashworth, A; Lord, CJ; Cancelliere, C; Bardelli, A; Seneci, P; Walczak, H; Delia, D; Lecis, D (2015-05)
      KRAS is mutated in about 20-25% of all human cancers and especially in pancreatic, lung and colorectal tumors. Oncogenic KRAS stimulates several pro-survival pathways, but it also triggers the trans-activation of pro-apoptotic ...
    • Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization. 

      Iorns, E; Lord, CJ; Ashworth, A (2009-01)
      Tamoxifen is the most commonly used drug to treat breast cancer and acts by blocking ERalpha (oestrogen receptor alpha) signalling. Although highly effective, its usefulness is limited by the development of resistance. ...
    • Tumour-suppression function of KLF12 through regulation of anoikis. 

      Godin-Heymann, N; Brabetz, S; Murillo, MM; Saponaro, M; Santos, CR; Lobley, A; East, P; Chakravarty, P; Matthews, N; Kelly, G; Jordan, S; Castellano, E; Downward, J (2016-06)
      Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, ...
    • The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles. 

      Orme, MH; Liccardi, G; Moderau, N; Feltham, R; Wicky-John, S; Tenev, T; Aram, L; Wilson, R; Bianchi, K; Morris, O; Monteiro Domingues, C; Robertson, D; Tare, M; Wepf, A; Williams, D; Bergmann, A; Gstaiger, M; Arama, E; Ribeiro, PS; Meier, P (2016-03-10)
      Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensatory proliferation, morphology and cell migration. How caspases are activated under non-apoptotic conditions and process ...
    • The use of unfixed bone marrow trephines for multicolour flow cytometry. 

      Morilla, R; Moss, K; Nikolova, V; Marquardt, K; Duke, S; Adamowska, K; Fuller, L; Taifoor, A; Johnson, N; Zeisig, A; Morilla, A; Atra, A; Taussig, DC (2018-02)
      An adequate bone marrow aspirate is essential for a rapid diagnosis of acute leukaemia by multicolour flow cytometry enabling the simultaneous assessment of multiple antigens on the cell surface as well as intracellular ...
    • Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment. 

      Eisenblaetter, M; Flores-Borja, F; Lee, JJ; Wefers, C; Smith, H; Hueting, R; Cooper, MS; Blower, PJ; Patel, D; Rodriguez-Justo, M; Milewicz, H; Vogl, T; Roth, J; Tutt, A; Schaeffter, T; Ng, T (2017-01)
      Background Systemic cancer spread is preceded by the establishment of a permissive microenvironment in the target tissue of metastasis - the premetastatic niche. As crucial players in establishment of the pre-metastatic ...