Now showing items 1-2 of 2

    • APC/C is an essential regulator of centrosome clustering. 

      Drosopoulos, K; Tang, C; Chao, WC; Linardopoulos, S (2014-01)
      Centrosome amplification has been extensively associated with cancer. Cancer cells with extra centrosomes have the ability to cluster the extra centrosomes and divide in a bipolar fashion. Although a number of proteins ...
    • Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer. 

      Patel, N; Weekes, D; Drosopoulos, K; Gazinska, P; Noel, E; Rashid, M; Mirza, H; Quist, J; Brasó-Maristany, F; Mathew, S; Ferro, R; Pereira, AM; Prince, C; Noor, F; Francesch-Domenech, E; Marlow, R; de Rinaldis, E; Grigoriadis, A; Linardopoulos, S; Marra, P; Tutt, ANJ (2018-03-13)
      Triple negative breast cancers (TNBCs) lack recurrent targetable driver mutations but demonstrate frequent copy number aberrations (CNAs). Here, we describe an integrative genomic and RNAi-based approach that identifies ...