Now showing items 1-11 of 11

    • AMPK-independent inhibition of human macrophage ER stress response by AICAR. 

      Boß, M; Newbatt, Y; Gupta, S; Collins, I; Brüne, B; Namgaladze, D (2016-08-26)
      Obesity-associated insulin resistance is driven by inflammatory processes in response to metabolic overload. Obesity-associated inflammation can be recapitulated in cell culture by exposing macrophages to saturated fatty ...
    • Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach. 

      Went, M; Sud, A; Law, PJ; Johnson, DC; Weinhold, N; Försti, A; van Duin, M; Mitchell, JS; Chen, B; Kuiper, R; Stephens, OW; Bertsch, U; Campo, C; Einsele, H; Gregory, WM; Henrion, M; Hillengass, J; Hoffmann, P; Jackson, GH; Lenive, O; Nickel, J; Nöthen, MM; da Silva Filho, MI; Thomsen, H; Walker, BA; Broyl, A; Davies, FE; Langer, C; Hansson, M; Kaiser, M; Sonneveld, P; Goldschmidt, H; Hemminki, K; Nilsson, B; Morgan, GJ; Houlston, RS (2017-06-16)
    • Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis. 

      Shu, X; Wu, L; Khankari, NK; Shu, X-O; Wang, TJ; Michailidou, K; Bolla, MK; Wang, Q; Dennis, J; Milne, RL; Schmidt, MK; Pharoah, PDP; Andrulis, IL; Hunter, DJ; Simard, J; Easton, DF; Zheng, W; Breast Cancer Association Consortium (2019-06)
      <h4>Background</h4>In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common ...
    • Dietary fat and early-onset prostate cancer risk. 

      Lophatananon, A; Archer, J; Easton, D; Pocock, R; Dearnaley, D; Guy, M; Kote-Jarai, Z; O'Brien, L; Wilkinson, RA; Hall, AL; Sawyer, E; Page, E; Liu, J-F; Barratt, S; Rahman, AA; UK Genetic Prostate Cancer Study Collaborators; British Association of Urological Surgeons' Section of Oncology; Eeles, R; Muir, K (2010-05)
      The UK incidence of prostate cancer has been increasing in men aged < 60 years. Migrant studies and global and secular variation in incidence suggest that modifiable factors, including a high-fat diet, may contribute to ...
    • Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. 

      Abubakar, M; Chang-Claude, J; Ali, HR; Chatterjee, N; Coulson, P; Daley, F; Blows, F; Benitez, J; Milne, RL; Brenner, H; Stegmaier, C; Mannermaa, A; Rudolph, A; Sinn, P; Couch, FJ; Devilee, P; Tollenaar, RAEM; Seynaeve, C; Figueroa, J; Lissowska, J; Hewitt, S; Hooning, MJ; Hollestelle, A; Foekens, R; Koppert, LB; kConFab Investigators; Bolla, MK; Wang, Q; Jones, ME; Schoemaker, MJ; Keeman, R; Easton, DF; Swerdlow, AJ; Sherman, ME; Schmidt, MK; Pharoah, PD; Garcia-Closas, M (2018-08)
      Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ ...
    • Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer. 

      Painter, JN; O'Mara, TA; Marquart, L; Webb, PM; Attia, J; Medland, SE; Cheng, T; Dennis, J; Holliday, EG; McEvoy, M; Scott, RJ; Ahmed, S; Healey, CS; Shah, M; Gorman, M; Martin, L; Hodgson, SV; Beckmann, MW; Ekici, AB; Fasching, PA; Hein, A; Rübner, M; Czene, K; Darabi, H; Hall, P; Li, J; Dörk, T; Dürst, M; Hillemanns, P; Runnebaum, IB; Amant, F; Annibali, D; Depreeuw, J; Lambrechts, D; Neven, P; Cunningham, JM; Dowdy, SC; Goode, EL; Fridley, BL; Winham, SJ; Njølstad, TS; Salvesen, HB; Trovik, J; Werner, HMJ; Ashton, KA; Otton, G; Proietto, A; Mints, M; Tham, E; Bolla, MK; Michailidou, K; Wang, Q; Tyrer, JP; Hopper, JL; Peto, J; Swerdlow, AJ; Burwinkel, B; Brenner, H; Meindl, A; Brauch, H; Lindblom, A; Chang-Claude, J; Couch, FJ; Giles, GG; Kristensen, VN; Cox, A; Pharoah, PDP; Tomlinson, I; Dunning, AM; Easton, DF; Thompson, DJ; Spurdle, AB; AOCS Group; for RENDOCAS; National Study of Endometrial Cancer Genetics Group (NSECG); Australian National Endometrial Cancer Study Group (ANECS) (2016-11)
      <h4>Background</h4>The strongest known risk factor for endometrial cancer is obesity. To determine whether SNPs associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with endometrial cancer ...
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. 

      Scott, RA; Freitag, DF; Li, L; Chu, AY; Surendran, P; Young, R; Grarup, N; Stancáková, A; Chen, Y; Varga, TV; Yaghootkar, H; Luan, J; Zhao, JH; Willems, SM; Wessel, J; Wang, S; Maruthur, N; Michailidou, K; Pirie, A; van der Lee, SJ; Gillson, C; Al Olama, AA; Amouyel, P; Arriola, L; Arveiler, D; Aviles-Olmos, I; Balkau, B; Barricarte, A; Barroso, I; Garcia, SB; Bis, JC; Blankenberg, S; Boehnke, M; Boeing, H; Boerwinkle, E; Borecki, IB; Bork-Jensen, J; Bowden, S; Caldas, C; Caslake, M; CVD50 consortium; Cupples, LA; Cruchaga, C; Czajkowski, J; den Hoed, M; Dunn, JA; Earl, HM; Ehret, GB; Ferrannini, E; Ferrieres, J; Foltynie, T; Ford, I; Forouhi, NG; Gianfagna, F; Gonzalez, C; Grioni, S; Hiller, L; Jansson, J-H; Jørgensen, ME; Jukema, JW; Kaaks, R; Kee, F; Kerrison, ND; Key, TJ; Kontto, J; Kote-Jarai, Z; Kraja, AT; Kuulasmaa, K; Kuusisto, J; Linneberg, A; Liu, C; Marenne, G; Mohlke, KL; Morris, AP; Muir, K; Müller-Nurasyid, M; Munroe, PB; Navarro, C; Nielsen, SF; Nilsson, PM; Nordestgaard, BG; Packard, CJ; Palli, D; Panico, S; Peloso, GM; Perola, M; Peters, A; Poole, CJ; Quirós, JR; Rolandsson, O; Sacerdote, C; Salomaa, V; Sánchez, M-J; Sattar, N; Sharp, SJ; Sims, R; Slimani, N; Smith, JA; Thompson, DJ; Trompet, S; Tumino, R; van der A, DL; van der Schouw, YT; Virtamo, J; Walker, M; Walter, K; GERAD_EC Consortium; Neurology Working Group of the Cohorts for Heart; Aging Research in Genomic Epidemiology (CHARGE); Alzheimer’s Disease Genetics Consortium; Pancreatic Cancer Cohort Consortium; European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD); EPIC-InterAct; Abraham, JE; Amundadottir, LT; Aponte, JL; Butterworth, AS; Dupuis, J; Easton, DF; Eeles, RA; Erdmann, J; Franks, PW; Frayling, TM; Hansen, T; Howson, JMM; Jørgensen, T; Kooner, J; Laakso, M; Langenberg, C; McCarthy, MI; Pankow, JS; Pedersen, O; Riboli, E; Rotter, JI; Saleheen, D; Samani, NJ; Schunkert, H; Vollenweider, P; O'Rahilly, S; CHARGE consortium; CHD Exome+ Consortium; CARDIOGRAM Exome Consortium; Deloukas, P; Danesh, J; Goodarzi, MO; Kathiresan, S; Meigs, JB; Ehm, MG; Wareham, NJ; Waterworth, DM (2016-06)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • Influence of body habitus on dose parameters of nodal levels III to IV irradiation for breast cancer: comparison of 3 techniques. 

      Sabater, S; Gascon, M; Gutierrez-Perez, M; Berenguer, R; Donovan, EM; Harris, EJ; Arenas, M (2018-12)
      This study aimed to investigate the effect of body habitus on supraclavicular (SC) dose-volume histogram (DVH) parameters among breast cancer patients according to 3 different techniques. Three SC irradiation plans were ...
    • The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study. 

      Johansson, M; Carreras-Torres, R; Scelo, G; Purdue, MP; Mariosa, D; Muller, DC; Timpson, NJ; Haycock, PC; Brown, KM; Wang, Z; Ye, Y; Hofmann, JN; Foll, M; Gaborieau, V; Machiela, MJ; Colli, LM; Li, P; Garnier, J-G; Blanche, H; Boland, A; Burdette, L; Prokhortchouk, E; Skryabin, KG; Yeager, M; Radojevic-Skodric, S; Ognjanovic, S; Foretova, L; Holcatova, I; Janout, V; Mates, D; Mukeriya, A; Rascu, S; Zaridze, D; Bencko, V; Cybulski, C; Fabianova, E; Jinga, V; Lissowska, J; Lubinski, J; Navratilova, M; Rudnai, P; Benhamou, S; Cancel-Tassin, G; Cussenot, O; Weiderpass, E; Ljungberg, B; Tumkur Sitaram, R; Häggström, C; Bruinsma, F; Jordan, SJ; Severi, G; Winship, I; Hveem, K; Vatten, LJ; Fletcher, T; Larsson, SC; Wolk, A; Banks, RE; Selby, PJ; Easton, DF; Andreotti, G; Beane Freeman, LE; Koutros, S; Männistö, S; Weinstein, S; Clark, PE; Edwards, TL; Lipworth, L; Gapstur, SM; Stevens, VL; Carol, H; Freedman, ML; Pomerantz, MM; Cho, E; Wilson, KM; Gaziano, JM; Sesso, HD; Freedman, ND; Parker, AS; Eckel-Passow, JE; Huang, W-Y; Kahnoski, RJ; Lane, BR; Noyes, SL; Petillo, D; Teh, BT; Peters, U; White, E; Anderson, GL; Johnson, L; Luo, J; Buring, J; Lee, I-M; Chow, W-H; Moore, LE; Eisen, T; Henrion, M; Larkin, J; Barman, P; Leibovich, BC; Choueiri, TK; Lathrop, GM; Deleuze, J-F; Gunter, M; McKay, JD; Wu, X; Houlston, RS; Chanock, SJ; Relton, C; Richards, JB; Martin, RM; Davey Smith, G; Brennan, P (2019-01-03)
      <h4>Background</h4>Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers ...
    • Influence of obesity-related risk factors in the aetiology of glioma. 

      Disney-Hogg, L; Sud, A; Law, PJ; Cornish, AJ; Kinnersley, B; Ostrom, QT; Labreche, K; Eckel-Passow, JE; Armstrong, GN; Claus, EB; Il'yasova, D; Schildkraut, J; Barnholtz-Sloan, JS; Olson, SH; Bernstein, JL; Lai, RK; Swerdlow, AJ; Simon, M; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Chanock, S; Rajaraman, P; Johansen, C; Jenkins, RB; Melin, BS; Wrensch, MR; Sanson, M; Bondy, ML; Houlston, RS (2018-04)
      <h4>Background</h4>Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation ...
    • Mendelian randomization provides support for obesity as a risk factor for meningioma. 

      Takahashi, H; Cornish, AJ; Sud, A; Law, PJ; Disney-Hogg, L; Calvocoressi, L; Lu, L; Hansen, HM; Smirnov, I; Walsh, KM; Schramm, J; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Schildkraut, JM; Simon, M; Bondy, M; Wrensch, M; Wiemels, JL; Claus, EB; Turnbull, C; Houlston, RS (2019-01-22)
      Little is known about the causes of meningioma. Obesity and obesity-related traits have been reported in several epidemiological observational studies to be risk factors for meningioma. We performed an analysis of genetic ...