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HER3 Is an Actionable Target in Advanced Prostate Cancer. 

Gil, V; Miranda, S; Riisnaes, R; Gurel, B; D'Ambrosio, M; et al.
It has been recognized for decades that ERBB signaling is important in prostate cancer, but targeting ERBB receptors as a therapeutic strategy for prostate cancer has been ineffective clinically. However, we show here that ...
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A comprehensive model for heat-induced radio-sensitisation. 

Brüningk, SC; Ijaz, J; Rivens, I; Nill, S; Ter Haar, G; et al. (2018-06)
Combined radiotherapy (RT) and hyperthermia (HT) treatments may improve treatment outcome by heat induced radio-sensitisation. We propose an empirical cell survival model (AlphaR model) to describe this multimodality ...
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Leveraging Human Genetics to Guide Cancer Drug Development. 

Kinnersley, B; Sud, A; Coker, EA; Tym, JE; Di Micco, P; et al. (2018-12)
Purpose The high attrition rate of cancer drug development programs is a barrier to realizing the promise of precision oncology. We have examined whether the genetic insights from genome-wide association studies of cancer ...
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canSAR: updated cancer research and drug discovery knowledgebase. 

Bulusu, KC; Tym, JE; Coker, EA; Schierz, AC; Al-Lazikani, B (2014-01)
canSAR (http://cansar.icr.ac.uk) is a public integrative cancer-focused knowledgebase for the support of cancer translational research and drug discovery. Through the integration of biological, pharmacological, chemical, ...
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Improving the efficiency of breast radiotherapy treatment planning using a semi-automated approach. 

Mitchell, RA; Wai, P; Colgan, R; Kirby, AM; Donovan, EM (2017-01)
Objectives To reduce treatment planning times while maintaining plan quality through the introduction of semi-automated planning techniques for breast radiotherapy.Methods Automatic critical structure delineation was ...
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Comprehensive translocation and clonality detection in lymphoproliferative disorders by next-generation sequencing. 

Wren, D; Walker, BA; Brüggemann, M; Catherwood, MA; Pott, C; et al. (2017-02)
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Heterogeneity in global gene expression profiles between biopsy specimens taken peri-surgically from primary ER-positive breast carcinomas. 

López-Knowles, E; Gao, Q; Cheang, MCU; Morden, J; Parker, J; et al. (2016-04)
Background Gene expression is widely used for the characterisation of breast cancers. Variability due to tissue heterogeneity or measurement error or systematic change due to peri-surgical procedures can affect measurements ...
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A comparison of the diagnostic value of MRI and 18 F-FDG-PET/CT in suspected spondylodiscitis. 

Smids, C; Kouijzer, IJE; Vos, FJ; Sprong, T; Hosman, AJF; et al. (2017-02)
Purpose The purpose of this study was to evaluate the diagnostic value of 18 F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing ...
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Mean heart dose variation over a course of breath-holding breast cancer radiotherapy. 

Dunkerley, N; Bartlett, FR; Kirby, AM; Evans, PM; Donovan, EM (2016-11)
Objective The purpose of the work was to estimate the dose received by the heart throughout a course of breath-holding breast radiotherapy.Methods 113 cone-beam CT (CBCT) scans were acquired for 20 patients treated within ...
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Reply from Authors re: Tillmann Loch, Pat Fox Fulgham. Active Surveillance Challenges in Men with Prostate Cancer: Role of Imaging Today and Tomorrow. Eur Urol 2016;69:1034-6: Imaging in Active Surveillance for Prostate Cancer: Where Should We Focus Our Research? 

Henderson, DR; de Souza, NM; Parker, CC; van As, NJ (2016-06)
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AuthorMarsden, (503)De Bono, Johann (157)Houlston, Richard (127)Eeles, Rosalind (118)Harrington, Kevin (118)... View MoreSubject
Humans (2685)
Female (1185)Male (1013)Middle Aged (825)Aged (707)... View MoreDate Issued2020 - 2023 (437)2010 - 2019 (2036)2001 - 2009 (93)Publication TypeJournal Article (2659)Other (16)Conference Proceeding (8)Chapter (1)Report (1)
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