Search
Now showing items 31-40 of 2016
Targeting the tumour microenvironment with endosialin-directed CAR T-cells
(Institute of Cancer Research (University Of London), 2022-05-31)
Advances in T-cell engineering have facilitated the generation of CAR T-cells that successfully deplete malignant cells of haematological cancers. However, attempts to target solid tumours with CAR T-cells have been hindered ...
The value of elective pelvic lymph node radiotherapy in high risk prostate cancer
(Institute of Cancer Research (University Of London), 2021-04-30)
High risk prostate cancer patients carry a high risk of microscopic pelvic lymph node (PLN) disease; however, the clinical benefit elective PLN radiotherapy remains unproven due to conflicting results from clinical trials. ...
Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations: Results from a Multi-institutional European Retrospective Study.
(2021-10-06)
<h4>Purpose</h4>The effect of high-dose imatinib (800 mg/day) on survival in the adjuvant treatment of patients with resected KIT exon 9-mutated gastrointestinal stromal tumors (GIST) is not established. Here, the association ...
Development of methods to assess the predictive power of pre-therapy imaging for selective internal radiation therapy
(Institute of Cancer Research (University Of London), 2020-12-31)
Pre-therapy Technetium-99m (99mTc)-MAA SPECT may be used to predict the 90Y absorbed dose in selective internal radiation therapy (SIRT), while post-therapy 90Y bremsstrahlung SPECT may be used to measure the delivered ...
Measuring tumour evolution at the genetic and epigenetic level in individual patients from cancer genomic data
(Institute of Cancer Research (University Of London), 2020-01-31)
High-throughput genomic data from cancers uncovered high intra and inter-tumour heterogeneity and subclonal architecture of cancer cell populations. If we consider cells as asexually reproducing individuals, we can apply ...
The use of germline genetic profiles to guide prostate cancer targeted screening and cancer care
(Institute of Cancer Research (University Of London), 2020-09-30)
The genetic heritability of prostate cancer is contributed to by rarely occurring but high penetrant genetic variants, and moderate to commonly occurring variants conferring lower risks. Genome wide association studies and ...
3-Dimensional objective aesthetic evaluation to replace panel assessment after breast-conserving treatment.
(2020-11)
Background Two-thirds of patients with early breast cancer undergo breast-conserving treatment (BCT). Aesthetic outcome is important and has long term implications for psychosocial wellbeing. The aesthetic goal of BCT is ...
"I was seen by a radiologist, but unfortunately I can't remember the name and I still have questions. What should I do?" Radiologists should give thoughts to improve service professionalism and patient esteem.
(2020-02-13)
BACKGROUND:The aim of the study is to investigate how well patients remember the radiologist's name after a radiological examination, and whether giving the patient a business card improves the patient's perception of the ...