Now showing items 1-10 of 175
Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA
The human tumor suppressor gene ataxia telangiectasia mutated (ATM) encodes a 3056 amino-acid protein kinase that regulates cell cycle checkpoints. ATM is defective in the neurodegenerative and cancer predisposition syndrome ...
Screening for breast cancer in India - Is it an appropriate strategy?
(OXFORD UNIV PRESS INC, 2008-09-17)
Activation of either ERK1/2 or ERK5 MAP kinase pathways can lead to disruption of the actin cytoskeleton.
Oncogenic transformation often leads to the disruption of the actin cytoskeleton. Activation of the classical Ras-Raf-MEK1/2-ERK1/2 signalling cascade has been implicated in the effects of oncogenes such as Ras and Src on ...
Ki-67 and outcome in clinically localised prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study
(NATURE PUBLISHING GROUP, 2009-03-17)
Treatment decisions after diagnosis of clinically localised prostate cancer are difficult due to variability in tumour behaviour. We therefore examined one of the most promising biomarkers in prostate cancer, Ki-67, in a ...
Randomized trial of porcarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: A medical research council trial
Purpose: Meta-analyses of the published literature suggest ct survival benefit to adjuvant chemotherapy for high-grade astrocytoma, which individual sma trials have been unable to demonstrate reliably. The Medical Research ...
Effect of testing for human papillomavirus as a triage during screening for cervical cancer: observational before and after study
(B M J PUBLISHING GROUP, 2006-01-14)
Objective To assess the effect of introducing testing for human papillomavirus combined with liquid based cytology in women with low grade cytological abnormalities. Design Observational before and after study. Setting ...
The roles of conserved amino acids on substrate binding and conformational integrity of ClpB N-terminal domain
(AMER CHEMICAL SOC, 2006-07-18)
Escherichia coli heat shock protein ClpB disaggregates denatured protein in cooperation with the DnaK chaperone system. Several studies showed that the N-terminal domain is essential for the chaperone activity, but its ...
Overdiagnosis and overtreatment of breast cancer - Overdiagnosis in randomised controlled trials of breast cancer screening
(BIOMED CENTRAL LTD, 2005)
Data from randomised controlled trials of mammographic screening can be used to determine the extent of any overdiagnosis, as soon as either a time equivalent to the lead-time has elapsed after the final screen, or the ...
Population screening for colorectal cancer: the implications of an ageing population
(NATURE PUBLISHING GROUP, 2008-12-09)
Population screening for colorectal cancer (CRC) has recently commenced in the United Kingdom supported by the evidence of a number of randomised trials and pilot studies. Certain factors are known to influence screening ...
An investigation into the number of appointment changes and queries arising as a result of extending breast screening to older women in the United Kingdom
(BRITISH MED JOURNAL PUBL GROUP, 2002)
Objective: To compare the number of telephone queries and appointment changes requested by women aged 65-69 with women aged 50-64. Setting: Department of Health funded demonstration study of extending breast screening to ...