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Ki-67 and outcome in clinically localised prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study
(NATURE PUBLISHING GROUP, 2009-03-17)
Treatment decisions after diagnosis of clinically localised prostate cancer are difficult due to variability in tumour behaviour. We therefore examined one of the most promising biomarkers in prostate cancer, Ki-67, in a ...
Concepts of epigenetics in prostate cancer development
(NATURE PUBLISHING GROUP, 2009-01-22)
Substantial evidence now supports the view that epigenetic changes have a role in the development of human prostate cancer. Analyses of the patterns of epigenetic alteration are providing important insights into the origin ...
Multigene expression of protein complexes by iterative modification of genomic Bacmid DNA
(BIOMED CENTRAL LTD, 2009-09-02)
Background: Many cellular multi-protein complexes are naturally present in cells at low abundance. Baculovirus expression offers one approach to produce milligram quantities of correctly folded and processed eukaryotic ...
MoKCa database--mutations of kinases in cancer.
(OXFORD UNIV PRESS, 2009-01-01)
Members of the protein kinase family are amongst the most commonly mutated genes in human cancer, and both mutated and activated protein kinases have proved to be tractable targets for the development of new anticancer ...