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dc.contributor.authorRamsay, EP
dc.contributor.authorVannini, A
dc.date.accessioned2018-01-24T12:12:26Z
dc.date.issued2018-04
dc.identifier.citationBiochimica et biophysica acta. Gene regulatory mechanisms, 2018, 1861 (4), pp. 285 - 294
dc.identifier.issn1874-9399
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1013
dc.identifier.eissn1876-4320
dc.identifier.doi10.1016/j.bbagrm.2017.11.005
dc.description.abstractRNA polymerase III catalyses the synthesis of tRNAs in eukaryotic organisms. Through combined biochemical and structural characterisation, multiple auxiliary factors have been identified alongside RNA Polymerase III as critical in both facilitating and regulating transcription. Together, this machinery forms dynamic multi-protein complexes at tRNA genes which are required for polymerase recruitment, DNA opening and initiation and elongation of the tRNA transcripts. Central to the function of these complexes is their ability to undergo multiple conformational changes and rearrangements that regulate each step. Here, we discuss the available biochemical and structural data on the structural plasticity of multi-protein complexes involved in RNA Polymerase III transcriptional initiation and facilitated re-initiation during tRNA synthesis. Increasingly, structural information is becoming available for RNA polymerase III and its functional complexes, allowing for a deeper understanding of tRNA transcriptional initiation. This article is part of a Special Issue entitled: SI: Regulation of tRNA synthesis and modification in physiological conditions and disease edited by Dr. Boguta Magdalena.
dc.formatPrint-Electronic
dc.format.extent285 - 294
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectEukaryotic Cells
dc.subjectAnimals
dc.subjectHumans
dc.subjectMultiprotein Complexes
dc.subjectRNA Polymerase III
dc.subjectProtein Subunits
dc.subjectTranscription Factors
dc.subjectRNA, Transfer
dc.subjectRNA, Transfer, Amino Acid-Specific
dc.subjectModels, Genetic
dc.subjectPromoter Regions, Genetic
dc.subjectTranscription Elongation, Genetic
dc.subjectTranscription Initiation, Genetic
dc.titleStructural rearrangements of the RNA polymerase III machinery during tRNA transcription initiation.
dc.typeJournal Article
dcterms.dateAccepted2017-11-11
rioxxterms.versionofrecord10.1016/j.bbagrm.2017.11.005
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2018-04
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBiochimica et biophysica acta. Gene regulatory mechanisms
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology/Vannini Group
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology/Vannini Group
pubs.publication-statusPublished
pubs.volume1861
pubs.embargo.termsNot known
icr.researchteamVannini Groupen_US
dc.contributor.icrauthorVannini, Alessandroen


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