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dc.contributor.authorKouijzer, IJE
dc.contributor.authorScheper, H
dc.contributor.authorde Rooy, JWJ
dc.contributor.authorBloem, JL
dc.contributor.authorJanssen, MJR
dc.contributor.authorvan den Hoven, L
dc.contributor.authorHosman, AJF
dc.contributor.authorVisser, LG
dc.contributor.authorOyen, WJG
dc.contributor.authorBleeker-Rovers, CP
dc.contributor.authorde Geus-Oei, L-F
dc.date.accessioned2018-01-26T09:34:35Z
dc.date.issued2018-05
dc.identifier.citationEuropean journal of nuclear medicine and molecular imaging, 2018, 45 (5), pp. 798 - 805
dc.identifier.issn1619-7070
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1031
dc.identifier.eissn1619-7089
dc.identifier.doi10.1007/s00259-017-3912-0
dc.description.abstractPURPOSE:The aim of this study was to determine the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. METHODS:From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F-FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others' image interpretation. 18F-FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. RESULTS:For 18F-FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F-FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0%). CONCLUSION:18F-FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F-FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.
dc.formatPrint-Electronic
dc.format.extent798 - 805
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectSpine
dc.subjectHumans
dc.subjectOsteomyelitis
dc.subjectFluorodeoxyglucose F18
dc.subjectRadiopharmaceuticals
dc.subjectPositron-Emission Tomography
dc.subjectTomography, X-Ray Computed
dc.subjectMagnetic Resonance Imaging
dc.subjectSensitivity and Specificity
dc.subjectProspective Studies
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectPositron Emission Tomography Computed Tomography
dc.titleThe diagnostic value of 18F-FDG-PET/CT and MRI in suspected vertebral osteomyelitis - a prospective study.
dc.typeJournal Article
dcterms.dateAccepted2017-12-10
rioxxterms.versionofrecord10.1007/s00259-017-3912-0
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfEuropean journal of nuclear medicine and molecular imaging
pubs.issue5
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Molecular Imaging
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Molecular Imaging
pubs.publication-statusPublished
pubs.volume45
pubs.embargo.termsNot known
icr.researchteamTranslational Molecular Imagingen_US
dc.contributor.icrauthorOyen, Willemen


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