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dc.contributor.authorKouijzer, IJEen_US
dc.contributor.authorScheper, Hen_US
dc.contributor.authorde Rooy, JWJen_US
dc.contributor.authorBloem, JLen_US
dc.contributor.authorJanssen, MJRen_US
dc.contributor.authorvan den Hoven, Len_US
dc.contributor.authorHosman, AJFen_US
dc.contributor.authorVisser, LGen_US
dc.contributor.authorOyen, WJGen_US
dc.contributor.authorBleeker-Rovers, CPen_US
dc.contributor.authorde Geus-Oei, L-Fen_US
dc.coverage.spatialGermanyen_US
dc.date.accessioned2018-01-26T09:34:35Z
dc.date.issued2018-05en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29256136en_US
dc.identifier10.1007/s00259-017-3912-0en_US
dc.identifier.citationEur J Nucl Med Mol Imaging, 2018, 45 (5), pp. 798 - 805en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1031
dc.identifier.eissn1619-7089en_US
dc.identifier.doi10.1007/s00259-017-3912-0en_US
dc.description.abstractPURPOSE: The aim of this study was to determine the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. METHODS: From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F-FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others' image interpretation. 18F-FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. RESULTS: For 18F-FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F-FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0%). CONCLUSION: 18F-FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F-FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.en_US
dc.format.extent798 - 805en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subject18F–Fdg-pet/cten_US
dc.subjectAbscessesen_US
dc.subjectMRIen_US
dc.subjectVertebral osteomyelitisen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectFemaleen_US
dc.subjectFluorodeoxyglucose F18en_US
dc.subjectHumansen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectOsteomyelitisen_US
dc.subjectPositron Emission Tomography Computed Tomographyen_US
dc.subjectPositron-Emission Tomographyen_US
dc.subjectProspective Studiesen_US
dc.subjectRadiopharmaceuticalsen_US
dc.subjectSensitivity and Specificityen_US
dc.subjectSpineen_US
dc.subjectTomography, X-Ray Computeden_US
dc.titleThe diagnostic value of 18F-FDG-PET/CT and MRI in suspected vertebral osteomyelitis - a prospective study.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-12-10en_US
rioxxterms.versionofrecord10.1007/s00259-017-3912-0en_US
rioxxterms.licenseref.startdate2018-05en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfEur J Nucl Med Mol Imagingen_US
pubs.issue5en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Molecular Imaging
pubs.publication-statusPublisheden_US
pubs.volume45en_US
pubs.embargo.termsNot knownen_US
icr.researchteamTranslational Molecular Imagingen_US
dc.contributor.icrauthorOyen, Willemen_US


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