Total energy expenditure and vigorous-intensity physical activity are associated with reduced odds of reclassification among men on active surveillance.
Date
2018-06Author
Guy, DE
Vandersluis, A
Klotz, LH
Fleshner, N
Kiss, A
Parker, C
Venkateswaran, V
Type
Journal Article
Metadata
Show full item recordAbstract
BACKGROUND:Research examining the association between physical activity (PA) and prostate cancer (PCa) has accumulated; however, few studies have examined this association in the context of active surveillance. The current study examines this among men initially diagnosed with favorable-risk PCa and managed by active surveillance at Sunnybrook Health Sciences Centre in Canada and the Royal Marsden Hospital in the United Kingdom. METHODS:Participants completed a questionnaire on daily participation in non-leisure, transport, and recreational PA. A logistic regression was employed using PA as the independent variable and whether the patient reclassified to higher-risk PCa while on active surveillance as the dependent variable. Demographic and lifestyle covariates were incorporated in the analysis to assess potential confounding and effect modification. RESULTS:Men from both hospitals presented with similar clinical and demographic characteristics. Total PA was inversely associated with odds of reclassification while on active surveillance (p-trend = 0.027). A weaker inverse association was observed with recreational PA (p-trend = 0.30). Men who participated in weekly vigorous PA were less likely to reclassify than those who did not (odds ratio (95% confidence interval): 0.42 (0.20-0.85)). CONCLUSIONS:Total and vigorous PA were inversely associated with odds of reclassification in two active surveillance cohorts. Given the limitations of this study, more robust prospective observational studies involving objective PA measures are warranted to confirm findings.
Collections
Subject
Humans
Prostatic Neoplasms
Disease Progression
Prostate-Specific Antigen
Prognosis
Exercise
Population Surveillance
Risk Factors
Cohort Studies
Follow-Up Studies
Motor Activity
Life Style
Energy Metabolism
Time Factors
Aged
Middle Aged
Male
Surveys and Questionnaires
Language
eng
Date accepted
2017-09-20
License start date
2018-06
Citation
Prostate cancer and prostatic diseases, 2018, 21 (2), pp. 187 - 195