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dc.contributor.authorHarvey, Hen_US
dc.contributor.authorMorgan, Ven_US
dc.contributor.authorFromageau, Jen_US
dc.contributor.authorO'Shea, Ten_US
dc.contributor.authorBamber, Jen_US
dc.contributor.authordeSouza, NMen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2018-02-13T10:29:38Z
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29353529en_US
dc.identifier.citationUltrason Imaging, 40 (3), pp. 158 - 170en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1049
dc.identifier.eissn1096-0910en_US
dc.identifier.doi10.1177/0161734618754487en_US
dc.description.abstractThe purpose of this study was to establish interobserver reproducibility of Young's modulus (YM) derived from ultrasound shear wave elastography (US-SWE) in the normal prostate and correlate it with multiparametric magnetic resonance imaging (mpMRI) tissue characteristics. Twenty men being screened for prostate cancer underwent same-day US-SWE (10 done by two blinded, newly-trained observers) and mpMRI followed by 12-core biopsy. Bland-Altman plots established limits of agreement for YM. Quantitative data from the peripheral zone (PZ) and the transitional zone (TZ) for YM, apparent diffusion coefficient (ADC, mm2/s from diffusion-weighted MRI), and Ktrans (volume transfer coefficient, min-1), Ve (extravascular-extracellular space, %), Kep (rate constant, /min), and initial area under the gadolinium concentration curve (IAUGC60, mmol/L/s) from dynamic contrast-enhanced MRI were obtained for slice-matched prostate sextants. Interobserver intraclass correlation coefficients were fair to good for individual regions (PZ = 0.57, TZ = 0.65) and for whole gland 0.67, (increasing to 0.81 when corrected for systematic observer bias). In the PZ, there were weak negative correlations between YM and ADC ( p = 0.008), and Ve ( p = 0.01) and a weak positive correlation with Kep ( p = 0.003). No significant intermodality correlations were seen in the TZ. Transrectal prostate US-SWE done without controlling manually applied probe pressure has fair/good interobserver reproducibility in inexperienced observers with potential to improve this to excellent by standardization of probe contact pressure. Within the PZ, increase in tissue stiffness is associated with reduced extracellular water (decreased ADC) and space (reduced Ve).en_US
dc.format.extent158 - 170en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectdiffusion-weighted MRIen_US
dc.subjectdynamic contrast–enhanceden_US
dc.subjectprostate canceren_US
dc.subjectreproducibilityen_US
dc.subjectultrasound shear wave elastographyen_US
dc.titleUltrasound Shear Wave Elastography of the Normal Prostate: Interobserver Reproducibility and Comparison with Functional Magnetic Resonance Tissue Characteristics.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-01-20en_US
rioxxterms.versionofrecord10.1177/0161734618754487en_US
rioxxterms.licenseref.startdate2018-01-20en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfUltrason Imagingen_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Ultrasound & Optical Imaging
pubs.publication-statusPublisheden_US
pubs.volume40en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMagnetic Resonanceen_US
icr.researchteamUltrasound & Optical Imagingen_US
dc.contributor.icrauthorBamber, Jeffreyen_US
dc.contributor.icrauthordeSouza, Nanditaen_US


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