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dc.contributor.authorBarnes, A
dc.contributor.authorAlonzi, R
dc.contributor.authorBlackledge, M
dc.contributor.authorCharles-Edwards, G
dc.contributor.authorCollins, DJ
dc.contributor.authorCook, G
dc.contributor.authorCoutts, G
dc.contributor.authorGoh, V
dc.contributor.authorGraves, M
dc.contributor.authorKelly, C
dc.contributor.authorKoh, D-M
dc.contributor.authorMcCallum, H
dc.contributor.authorMiquel, ME
dc.contributor.authorO'Connor, J
dc.contributor.authorPadhani, A
dc.contributor.authorPearson, R
dc.contributor.authorPriest, A
dc.contributor.authorRockall, A
dc.contributor.authorStirling, J
dc.contributor.authorTaylor, S
dc.contributor.authorTunariu, N
dc.contributor.authorvan der Meulen, J
dc.contributor.authorWalls, D
dc.contributor.authorWinfield, J
dc.contributor.authorPunwani, S
dc.date.accessioned2018-02-13T16:42:50Z
dc.date.issued2018-01
dc.identifier.citationThe British journal of radiology, 2018, 91 (1081), pp. 20170577 - ?
dc.identifier.issn0007-1285
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1058
dc.identifier.eissn1748-880X
dc.identifier.doi10.1259/bjr.20170577
dc.description.abstractObjective Application of whole body diffusion-weighted MRI (WB-DWI) for oncology are rapidly increasing within both research and routine clinical domains. However, WB-DWI as a quantitative imaging biomarker (QIB) has significantly slower adoption. To date, challenges relating to accuracy and reproducibility, essential criteria for a good QIB, have limited widespread clinical translation. In recognition, a UK workgroup was established in 2016 to provide technical consensus guidelines (to maximise accuracy and reproducibility of WB-MRI QIBs) and accelerate the clinical translation of quantitative WB-DWI applications for oncology.Methods A panel of experts convened from cancer centres around the UK with subspecialty expertise in quantitative imaging and/or the use of WB-MRI with DWI. A formal consensus method was used to obtain consensus agreement regarding best practice. Questions were asked about the appropriateness or otherwise on scanner hardware and software, sequence optimisation, acquisition protocols, reporting, and ongoing quality control programs to monitor precision and accuracy and agreement on quality control.Results The consensus panel was able to reach consensus on 73% (255/351) items and based on consensus areas made recommendations to maximise accuracy and reproducibly of quantitative WB-DWI studies performed at 1.5T. The panel were unable to reach consensus on the majority of items related to quantitative WB-DWI performed at 3T.Conclusion This UK Quantitative WB-DWI Technical Workgroup consensus provides guidance on maximising accuracy and reproducibly of quantitative WB-DWI for oncology. The consensus guidance can be used by researchers and clinicians to harmonise WB-DWI protocols which will accelerate clinical translation of WB-DWI-derived QIBs.
dc.formatPrint-Electronic
dc.format.extent20170577 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectMedical Oncology
dc.subjectQuality Control
dc.subjectWhole Body Imaging
dc.subjectUnited Kingdom
dc.titleUK quantitative WB-DWI technical workgroup: consensus meeting recommendations on optimisation, quality control, processing and analysis of quantitative whole-body diffusion-weighted imaging for cancer.
dc.typeJournal Article
dcterms.dateAccepted2017-10-11
rioxxterms.versionofrecord10.1259/bjr.20170577
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfThe British journal of radiology
pubs.issue1081
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Computational Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Quantitative Biomedical Imaging
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Computational Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Quantitative Biomedical Imaging
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume91
pubs.embargo.termsNot known
icr.researchteamComputational Imagingen_US
icr.researchteamQuantitative Biomedical Imagingen_US
dc.contributor.icrauthorKoh, Dow-Muen
dc.contributor.icrauthorBlackledge, Matthewen
dc.contributor.icrauthorTunariu, Ninaen
dc.contributor.icrauthorWinfield, Jessicaen
dc.contributor.icrauthorMarsden,en
dc.contributor.icrauthorO'Connor, James Patricken


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