Publications Repository

Publications Repository

View item 
  •   Home
  • ICR Divisions
  • Radiotherapy and Imaging
  • View item
  • Home
  • ICR Divisions
  • Radiotherapy and Imaging
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Post-relapse outcomes after primary extended resection of retroperitoneal sarcoma: A report from the Trans-Atlantic RPS Working Group.

Thumbnail
View/Open
Supporting information (63.31Kb)
Date
2017-06
ICR Author
Hayes, Andrew
Marsden,
Author
MacNeill, AJ
Miceli, R
Strauss, DC
Bonvalot, S
Hohenberger, P
Van Coevorden, F
Rutkowski, P
Callegaro, D
Hayes, AJ
Honoré, C
Fairweather, M
Cannell, A
Jakob, J
Haas, RL
Szacht, M
Fiore, M
Casali, PG
Pollock, RE
Raut, CP
Gronchi, A
Swallow, CJ
Show allShow less
Type
Journal Article
Metadata
Show full item record
Abstract
Background Despite a radical surgical approach to primary retroperitoneal sarcoma (RPS), many patients experience locoregional and/or distant recurrence. The objective of this study was to analyze post-relapse outcomes for patients with RPS who had initially undergone surgical resection of their primary tumor at a specialist center.Methods All consecutive patients who underwent macroscopically complete resection for primary RPS at 8 high volume centers from January 2002 to December 2011 were identified, and those who developed local recurrence (LR) only, distant metastasis (DM) only, or synchronous local recurrence and distant metastasis (LR+DM) during the follow-up period were included. Overall survival (OS) was calculated for all groups, as was the crude cumulative incidence of a second recurrence after the first LR. Multivariate analyses for OS were performed.Results In an initial series of 1007 patients with primary RPS, 408 patients developed recurrent disease during the follow-up period. The median follow-up from the time of recurrence was 41 months. The median OS was 33 months after LR (n = 219), 25 months after DM (n = 146), and 12 months after LR+DM (n = 43), and the 5-year OS rates were 29%, 20%, and 14%, respectively. Predictors of OS after LR were the time interval to LR and resection of LR, while histologic grade approached significance. For DM, significant predictors of OS were the time interval to DM and histologic subtype. The subgroup of patients who underwent resection of recurrent disease had a longer median OS than patients who did not undergo resection.Conclusions Relapse of RPS portends high disease-specific mortality. Patients with locally recurrent or metastatic disease should be considered for resection. Cancer 2017;123:1971-1978. © 2017 American Cancer Society.
URI
https://repository.icr.ac.uk/handle/internal/1068
DOI
https://doi.org/10.1002/cncr.30572
Collections
  • Radiotherapy and Imaging
Subject
Humans
Liposarcoma
Leiomyosarcoma
Sarcoma
Retroperitoneal Neoplasms
Neoplasm Metastasis
Neoplasm Recurrence, Local
Antineoplastic Agents
Radiotherapy
Survival Rate
Multivariate Analysis
Retrospective Studies
Aged
Middle Aged
Female
Male
Solitary Fibrous Tumors
Research team
Sarcoma and Melanoma Surgery
Language
eng
Date accepted
2016-12-28
License start date
2017-06
Citation
Cancer, 2017, 123 (11), pp. 1971 - 1978

Browse

All of ICR repositoryICR DivisionsBy issue dateAuthorsTitlesPublication TypesThis collectionBy issue dateAuthorsTitlesPublication Types
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.