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dc.contributor.authorMacNeill, AJen_US
dc.contributor.authorMiceli, Ren_US
dc.contributor.authorStrauss, DCen_US
dc.contributor.authorBonvalot, Sen_US
dc.contributor.authorHohenberger, Pen_US
dc.contributor.authorVan Coevorden, Fen_US
dc.contributor.authorRutkowski, Pen_US
dc.contributor.authorCallegaro, Den_US
dc.contributor.authorHayes, AJen_US
dc.contributor.authorHonoré, Cen_US
dc.contributor.authorFairweather, Men_US
dc.contributor.authorCannell, Aen_US
dc.contributor.authorJakob, Jen_US
dc.contributor.authorHaas, RLen_US
dc.contributor.authorSzacht, Men_US
dc.contributor.authorFiore, Men_US
dc.contributor.authorCasali, PGen_US
dc.contributor.authorPollock, REen_US
dc.contributor.authorRaut, CPen_US
dc.contributor.authorGronchi, Aen_US
dc.contributor.authorSwallow, CJen_US
dc.date.accessioned2018-02-14T10:49:55Z
dc.date.issued2017-06en_US
dc.identifier.citationCancer, 2017, 123 (11), pp. 1971 - 1978en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1068
dc.identifier.eissn1097-0142en_US
dc.identifier.doi10.1002/cncr.30572en_US
dc.description.abstract<h4>Background</h4>Despite a radical surgical approach to primary retroperitoneal sarcoma (RPS), many patients experience locoregional and/or distant recurrence. The objective of this study was to analyze post-relapse outcomes for patients with RPS who had initially undergone surgical resection of their primary tumor at a specialist center.<h4>Methods</h4>All consecutive patients who underwent macroscopically complete resection for primary RPS at 8 high volume centers from January 2002 to December 2011 were identified, and those who developed local recurrence (LR) only, distant metastasis (DM) only, or synchronous local recurrence and distant metastasis (LR+DM) during the follow-up period were included. Overall survival (OS) was calculated for all groups, as was the crude cumulative incidence of a second recurrence after the first LR. Multivariate analyses for OS were performed.<h4>Results</h4>In an initial series of 1007 patients with primary RPS, 408 patients developed recurrent disease during the follow-up period. The median follow-up from the time of recurrence was 41 months. The median OS was 33 months after LR (n = 219), 25 months after DM (n = 146), and 12 months after LR+DM (n = 43), and the 5-year OS rates were 29%, 20%, and 14%, respectively. Predictors of OS after LR were the time interval to LR and resection of LR, while histologic grade approached significance. For DM, significant predictors of OS were the time interval to DM and histologic subtype. The subgroup of patients who underwent resection of recurrent disease had a longer median OS than patients who did not undergo resection.<h4>Conclusions</h4>Relapse of RPS portends high disease-specific mortality. Patients with locally recurrent or metastatic disease should be considered for resection. Cancer 2017;123:1971-1978. © 2017 American Cancer Society.en_US
dc.formatPrint-Electronicen_US
dc.format.extent1971 - 1978en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectHumansen_US
dc.subjectLiposarcomaen_US
dc.subjectLeiomyosarcomaen_US
dc.subjectSarcomaen_US
dc.subjectRetroperitoneal Neoplasmsen_US
dc.subjectNeoplasm Metastasisen_US
dc.subjectNeoplasm Recurrence, Localen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectRadiotherapyen_US
dc.subjectSurvival Rateen_US
dc.subjectMultivariate Analysisen_US
dc.subjectRetrospective Studiesen_US
dc.subjectAgeden_US
dc.subjectMiddle Ageden_US
dc.subjectFemaleen_US
dc.subjectMaleen_US
dc.subjectSolitary Fibrous Tumorsen_US
dc.titlePost-relapse outcomes after primary extended resection of retroperitoneal sarcoma: A report from the Trans-Atlantic RPS Working Group.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-12-28en_US
rioxxterms.versionofrecord10.1002/cncr.30572en_US
rioxxterms.licenseref.startdate2017-06en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCanceren_US
pubs.issue11en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Sarcoma and Melanoma Surgery
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume123en_US
pubs.embargo.termsNot knownen_US
icr.researchteamSarcoma and Melanoma Surgeryen_US
dc.contributor.icrauthorHayes, Andrewen_US
dc.contributor.icrauthorMarsden,en_US


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