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dc.contributor.authorNecchi, Aen_US
dc.contributor.authorPond, GRen_US
dc.contributor.authorRaggi, Den_US
dc.contributor.authorOttenhof, SRen_US
dc.contributor.authorDjajadiningrat, RSen_US
dc.contributor.authorHorenblas, Sen_US
dc.contributor.authorKhoo, Ven_US
dc.contributor.authorHakenberg, OWen_US
dc.contributor.authorDraeger, Den_US
dc.contributor.authorProtzel, Cen_US
dc.contributor.authorHeidenreich, Aen_US
dc.contributor.authorHaidl, Fen_US
dc.contributor.authorEigl, BJen_US
dc.contributor.authorNappi, Len_US
dc.contributor.authorMatsumoto, Ken_US
dc.contributor.authorVaishampayan, Uen_US
dc.contributor.authorWoods, MEen_US
dc.contributor.authorSalvioni, Ren_US
dc.contributor.authorNicolai, Nen_US
dc.contributor.authorCatanzaro, Men_US
dc.contributor.authorGiannatempo, Pen_US
dc.contributor.authorGeynisman, DMen_US
dc.contributor.authorPreto, Men_US
dc.contributor.authorXylinas, Een_US
dc.contributor.authorMilowsky, MIen_US
dc.contributor.authorDe Placido, Sen_US
dc.contributor.authorDi Lorenzo, Gen_US
dc.contributor.authorSonpavde, Gen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2018-02-15T11:13:41Z
dc.date.issued2017-10en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28325636en_US
dc.identifierS1558-7673(17)30045-9en_US
dc.identifier.citationClin Genitourin Cancer, 2017, 15 (5), pp. 548 - 555.e3en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1097
dc.identifier.eissn1938-0682en_US
dc.identifier.doi10.1016/j.clgc.2017.02.002en_US
dc.description.abstractBACKGROUND: The prognosis of patients with locally advanced penile squamous-cell carcinoma is primarily related to the extent of lymph node metastases. Surgery alone yields suboptimal results, and there is a paucity of data on these patients' outcomes. PATIENTS AND METHODS: This retrospective study evaluated patients who received neoadjuvant or adjuvant chemotherapy from 1990 onward at 12 centers. Cox models were used to investigate prognostic factors for relapse-free survival and overall survival (OS). RESULTS: Among the 201 included patients, 39 (19.4%) had disease of T3-4 and N0 clinical stage; the remaining patients had clinical lymph node involvement (cN+). Ninety-four patients received neoadjuvant chemotherapy (group 1), 78 received adjuvant chemotherapy (group 2), and 21 received both (group 3). Eight patients for whom the timing of perioperative chemotherapy administration was unavailable were included in the Cox analyses. Forty-three patients (21.4%) received chemoradiation. Multivariate analysis for OS (n = 172) revealed bilateral disease (P = .035) as a negative prognostic factor, while pelvic cN+ tended to be nonsignificantly associated with decreased OS (P = .076). One-year relapse-free survival was 35.6%, 60.6%, and 45.1% in the 3 groups, respectively. One-year OS was 61.3%, 82.2%, and 75%, respectively. No significant differences were seen on univariable analyses for OS between the groups (P = .45). Platinum type of chemotherapy and chemoradiation were not significantly associated with any outcome analyzed. CONCLUSION: Benchmark survival estimates for patients receiving perioperative chemotherapy for locally advanced penile squamous-cell carcinoma have been provided, with no substantial differences observed between neoadjuvant and adjuvant administration. This analysis may result in improved patient information, although prospective studies are warranted.en_US
dc.format.extent548 - 555.e3en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectPenile canceren_US
dc.subjectPreoperative chemotherapyen_US
dc.subjectRegional lymph nodesen_US
dc.subjectSquamous cell carcinomaen_US
dc.subjectSurvivalen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectCarcinoma, Squamous Cellen_US
dc.subjectChemoradiotherapyen_US
dc.subjectChemotherapy, Adjuvanten_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectNeoadjuvant Therapyen_US
dc.subjectPenile Neoplasmsen_US
dc.subjectPerioperative Perioden_US
dc.subjectPrognosisen_US
dc.subjectProspective Studiesen_US
dc.subjectSurvival Analysisen_US
dc.subjectTreatment Outcomeen_US
dc.titleClinical Outcomes of Perioperative Chemotherapy in Patients With Locally Advanced Penile Squamous-Cell Carcinoma: Results of a Multicenter Analysis.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-02-19en_US
rioxxterms.versionofrecord10.1016/j.clgc.2017.02.002en_US
rioxxterms.licenseref.startdate2017-10en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfClin Genitourin Canceren_US
pubs.issue5en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume15en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorMarsden,en_US


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