dc.contributor.author | Campbell, J | |
dc.contributor.author | Ryan, CJ | |
dc.contributor.author | Brough, R | |
dc.contributor.author | Bajrami, I | |
dc.contributor.author | Pemberton, HN | |
dc.contributor.author | Chong, IY | |
dc.contributor.author | Costa-Cabral, S | |
dc.contributor.author | Frankum, J | |
dc.contributor.author | Gulati, A | |
dc.contributor.author | Holme, H | |
dc.contributor.author | Miller, R | |
dc.contributor.author | Postel-Vinay, S | |
dc.contributor.author | Rafiq, R | |
dc.contributor.author | Wei, W | |
dc.contributor.author | Williamson, CT | |
dc.contributor.author | Quigley, DA | |
dc.contributor.author | Tym, J | |
dc.contributor.author | Al-Lazikani, B | |
dc.contributor.author | Fenton, T | |
dc.contributor.author | Natrajan, R | |
dc.contributor.author | Strauss, SJ | |
dc.contributor.author | Ashworth, A | |
dc.contributor.author | Lord, CJ | |
dc.date.accessioned | 2016-09-14T09:49:43Z | |
dc.date.issued | 2016-03-15 | |
dc.identifier.citation | Cell reports, 2016, 14 (10), pp. 2490 - 2501 | |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/109 | |
dc.identifier.eissn | 2211-1247 | |
dc.identifier.doi | 10.1016/j.celrep.2016.02.023 | |
dc.description.abstract | One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to profile genetic dependencies in cancer cell lines. Here, we describe data from a series of siRNA screens that identify the kinase genetic dependencies in 117 cancer cell lines from ten cancer types. By integrating the siRNA screen data with molecular profiling data, including exome sequencing data, we show how vulnerabilities/genetic dependencies that are associated with mutations in specific cancer driver genes can be identified. By integrating additional data sets into this analysis, including protein-protein interaction data, we also demonstrate that the genetic dependencies associated with many cancer driver genes form dense connections on functional interaction networks. We demonstrate the utility of this resource by using it to predict the drug sensitivity of genetically or histologically defined subsets of tumor cell lines, including an increased sensitivity of osteosarcoma cell lines to FGFR inhibitors and SMAD4 mutant tumor cells to mitotic inhibitors. | |
dc.format | Print-Electronic | |
dc.format.extent | 2490 - 2501 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | CELL PRESS | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Cell Line, Tumor | |
dc.subject | Humans | |
dc.subject | Neoplasms | |
dc.subject | Protein Kinases | |
dc.subject | Receptor, erbB-2 | |
dc.subject | RNA, Small Interfering | |
dc.subject | Gene Expression Profiling | |
dc.subject | RNA Interference | |
dc.subject | Mutation | |
dc.subject | Receptor, Fibroblast Growth Factor, Type 1 | |
dc.subject | Smad4 Protein | |
dc.title | Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-02-01 | |
rioxxterms.versionofrecord | 10.1016/j.celrep.2016.02.023 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-03-03 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Cell reports | |
pubs.issue | 10 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Computational Biology and Chemogenomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Ashworth Collaborators | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Computational Biology and Chemogenomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Ashworth Collaborators | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function | |
pubs.publication-status | Published | |
pubs.volume | 14 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Computational Biology and Chemogenomics | |
icr.researchteam | Ashworth Collaborators | |
icr.researchteam | Functional Genomics | |
icr.researchteam | Gene Function | |
dc.contributor.icrauthor | Campbell, James | |
dc.contributor.icrauthor | Chong, Yu-Shing | |
dc.contributor.icrauthor | Al-Lazikani, Bissan | |
dc.contributor.icrauthor | Natrajan, Rachael | |
dc.contributor.icrauthor | Lord, Christopher | |