Browsing Other ICR Research by title
Now showing items 151-170 of 612
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Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer: the prospective Streamline C trial.
(ELSEVIER INC, 2019-07-01)BACKGROUND: Whole-body MRI (WB-MRI) could be an alternative to multimodality staging of colorectal cancer, but its diagnostic accuracy, effect on staging times, number of tests needed, cost, and effect on treatment decisions ... -
Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed non-small-cell lung cancer: the prospective Streamline L trial.
(ELSEVIER SCI LTD, 2019-06-01)BACKGROUND: Whole-body magnetic resonance imaging (WB-MRI) could be an alternative to multi-modality staging of non-small-cell lung cancer (NSCLC), but its diagnostic accuracy, effect on staging times, number of tests ... -
Differential effects of lenalidomide during plasma cell differentiation.
(IMPACT JOURNALS LLC, 2016-05-10)Thalidomide, lenalidomide and pomalidomide have greatly improved the outcome of patients with multiple myeloma. However, their effects on plasma cells, the healthy counterpart of myeloma cells, are unknown. Here, we ... -
Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System
(Elsevier BV, 2017-10-01) -
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
(2016-08)Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise. To catalog the rules governing how somatic ... -
A discrete ordinates Boltzmann solver for application to inverse planning of photons and protons.
(IOP Publishing, 2023-08-29)The aim of this work is to develop a discrete ordinates Boltzmann solver that can be used for calculation of absorbed dose from both photons and protons within an inverse planning optimizer, so as to perform accurate dose ... -
Discriminative identification of transcriptional responses of promoters and enhancers after stimulus
(2017-01-01)Promoters and enhancers regulate the initiation of gene expression and maintenance of expression levels in spatial and temporal manner. Recent findings stemming from the Cap Analysis of Gene Expression (CAGE) demonstrate ... -
DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation.
(OXFORD UNIV PRESS, 2022-01-07)The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report ... -
DisProt: intrinsic protein disorder annotation in 2020.
(OXFORD UNIV PRESS, 2020-01-08)The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version ... -
Divergent adaptation in thyroid cancers.
(OXFORD UNIV PRESS, 2018-06-01) -
DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization
(CELL PRESS, 2010-10-08)Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire their checkpoint response and become dependent on the ... -
Does Body Contouring After Bariatric Weight Loss Enhance Quality of Life? A Systematic Review of QOL Studies.
(2018-10)Massive weight loss following bariatric surgery can result in excess tissue, manifesting as large areas of redundant skin that can be managed by body contouring surgery. This study aims to quantify the effects of body ... -
Does mainstream BRCA testing affect surgical decision-making in newly-diagnosed breast cancer patients?
(Elsevier BV, 2023-02-01)BACKGROUND: Germline pathogenic variants mutations) in the BRCA1 and BRCA2 genes cause an increased risk of breast cancer and ovarian cancer. Mainstream cancer genetic testing (MCG) was introduced for breast cancer patients ... -
Does the addition of whole-body MRI to routine imaging influence real-world treatment decisions in metastatic breast cancer?
(BMC, 2022-06-07)BACKGROUND: The assessment of metastatic breast cancer (MBC) can be limited with routine imaging such as computed tomography (CT) especially in bone-only or bone-predominant disease. This analysis investigates the effects ... -
Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group).
(2018-09)PURPOSE:Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are still widely used. Modern techniques (IMRT, VMAT, TomoTherapy®, proton pencil beam scanning [PBS]) are applied in a limited number of centers. ... -
Dual Inhibitors of PARPs and ROCKs.
(AMER CHEMICAL SOC, 2018-10-31)Recent network and system biology analyses suggest that most complex diseases are regulated by robust and highly interconnected pathways that could be better modulated by small molecules binding to multiple biological ... -
Dual-view oblique plane microscopy (dOPM).
(OPTICAL SOC AMER, 2020-12-01)We present a new folded dual-view oblique plane microscopy (OPM) technique termed dOPM that enables two orthogonal views of the sample to be obtained by translating a pair of tilted mirrors in refocussing space. Using a ... -
DUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt’s lymphoma
(NATURE PUBLISHING GROUP, 2010-07-13)BACKGROUND: The mitogen-activated protein kinase (MAPK) phosphatases or dual specificity phosphatases (DUSPs) are a family of proteins that catalyse the inactivation of MAPK in eukaryotic cells. Little is known of the ... -
EANM dosimetry committee series on standard operational procedures: a unified methodology for 99mTc-MAA pre- and 90Y peri-therapy dosimetry in liver radioembolization with 90Y microspheres.
(SPRINGER, 2021-11-12)The aim of this standard operational procedure is to standardize the methodology employed for the evaluation of pre- and post-treatment absorbed dose calculations in 90Y microsphere liver radioembolization. Basic assumptions ...