Browsing Other ICR Research by title
Now showing items 284-303 of 612
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Influence of molecular imaging on patient selection for treatment intensification prior to salvage radiation therapy for prostate cancer: a post hoc analysis of the PROPS trial.
(BMC, 2023-06-08)BACKGROUND: The impact of molecular imaging (MI) on patient management after biochemical recurrence (BCR) following radical prostatectomy has been described in many studies. However, it is not known if MI-induced management ... -
Inhibited, trapped or adducted: the optimal selective synthetic lethal mix for BRCAness.
(OXFORD UNIV PRESS, 2018-01-01) -
Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation.
(CELL PRESS, 2016-01-14)Eukaryotic ribosome biogenesis depends on several hundred assembly factors to produce functional 40S and 60S ribosomal subunits. The final phase of 60S subunit biogenesis is cytoplasmic maturation, which includes the ... -
Integrated MRI-guided radiotherapy - opportunities and challenges.
(2022-04-19)MRI can help to categorize tissues as malignant or non-malignant both anatomically and functionally, with a high level of spatial and temporal resolution. This non-invasive imaging modality has been integrated with ... -
Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727).
(AMER ASSOC CANCER RESEARCH, 2023-09-15)PURPOSE: The TNT trial (NCT00532727) showed no evidence of carboplatin superiority over docetaxel in metastatic triple-negative breast cancer (mTNBC), but carboplatin benefit was observed in the germline BRCA1/2 mutation ... -
Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer.
(CELL PRESS, 2018-11-06)Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, there remains controversy as to the mode of action of metformin in tumors at clinical doses. We conducted a clinical study ... -
Integrating the OHIF Viewer into XNAT: Achievements, Challenges and Prospects for Quantitative Imaging Studies.
(MDPI, 2022-02-11)Purpose: XNAT is an informatics software platform to support imaging research, particularly in the context of large, multicentre studies of the type that are essential to validate quantitative imaging biomarkers. XNAT ... -
Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer.
(CELL PRESS, 2019-05-14)Lymphatic vasculature is crucial for metastasis in triple-negative breast cancer (TNBC); however, cellular and molecular drivers controlling lymphovascular metastasis are poorly understood. We define a macrophage-dependent ... -
Inter-comparison of quantitative imaging of lutetium-177 (177Lu) in European hospitals.
(SPRINGEROPEN, 2018-08-02)BACKGROUND: This inter-comparison exercise was performed to demonstrate the variability of quantitative SPECT/CT imaging for lutetium-177 (177Lu) in current clinical practice. Our aim was to assess the feasibility of using ... -
Intestinal Epithelial Cells and the Microbiome Undergo Swift Reprogramming at the Inception of Colonic Citrobacter rodentium Infection.
(AMER SOC MICROBIOLOGY, 2019-04-02)We used the mouse attaching and effacing (A/E) pathogen Citrobacter rodentium, which models the human A/E pathogens enteropathogenic Escherichia coli and enterohemorrhagic E. coli (EPEC and EHEC), to temporally resolve ... -
Intimate partner violence crisis in the COVID-19 pandemic: how can radiologists make a difference?
(2020-12)Key points • The COVID-19 crisis resulted in a variety of physical and mental health issues beyond the viral infection itself, as indicated by an increase in domestic violence.• Radiologists should be aware of typical ... -
An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment.
(Springer Science and Business Media LLC, 2022-10-17)Protein phosphorylation is a major regulatory mechanism of cellular signalling. The c-JUN proto-oncoprotein is phosphorylated at four residues within its transactivation domain (TAD) by the JNK family kinases, but the ... -
Introduction to the National Cancer Imaging Translational Accelerator (NCITA): a UK-wide infrastructure for multicentre clinical translation of cancer imaging biomarkers.
(SPRINGERNATURE, 2021-11-23)The National Cancer Imaging Translational Accelerator (NCITA) is creating a UK national coordinated infrastructure for accelerated translation of imaging biomarkers for clinical use. Through the development of standardised ... -
Intuitive Gaze-Control of a Robotized Flexible Endoscope
(IEEE, 2018-01-01) -
Inverse planning of lung radiotherapy with photon and proton beams using a discrete ordinates Boltzmann solver.
(IOP Publishing Ltd, 2024-02-02)Objective. A discrete ordinates Boltzmann solver has recently been developed for use as a fast and accurate dose engine for calculation of photon and proton beams. The purpose of this study is to apply the algorithm to the ... -
Investigating determinants of sensitivity and resistance to T cell redirecting antibodies in colorectal cancer through patient derived organoid models
(Institute of Cancer Research (University Of London), 2023-06-12)Most colorectal cancers (CRCs) do not respond to treatment with immune-checkpoint-inhibitors due to modest mutation loads, low cytotoxic T cell infiltrates, and immunosuppressive microenvironments. The CEA-TCB bispecific ... -
Isotope-Only Localization for Sentinel Lymph Node Biopsy - Medium-Term Oncological Outcomes.
<h4>Aims</h4>Isotope and blue dye dual localization in sentinel lymph node biopsy (SLNB) gives localization rates of over 98% and is the recommended technique. However blue dye risks a range of adverse reactions. Since ... -
JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers.
(Wiley, 2016-12-01)BACKGROUND: Lung remodeling and pulmonary fibrosis are serious, life-threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that ... -
Kaposi’s sarcoma-associated herpesvirus-infected primary effusion lymphoma has a gene expression profile
(2003-09-02)Kaposi’s sarcoma-associated herpesvirus is associated with three human tumors: Kaposi’s sarcoma, and the B cell lymphomas, plasmablastic lymphoma associated with multicentric Castleman’s disease, and primary effusion ...