Browsing Other ICR Research by title
Now showing items 546-565 of 612
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The expected burden of mesothelioma mortality in Great Britain from 2002 to 2050
(NATURE PUBLISHING GROUP, 2005-02-14)The British mesothelioma register contains all deaths from 1968 to 2001 where mesothelioma was mentioned on the death certificate. These data were used to predict the future burden of mesothelioma mortality in Great Britain. ... -
The functional importance of structure in unstructured protein regions.
(CURRENT BIOLOGY LTD, 2019-06-01)After two decades of research, intrinsically disordered regions (IDRs) are established as a widespread phenomenon. The growing understanding of the significant functional role of IDRs has challenged the structure-function ... -
The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2).
(2017-02)Objective Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this ... -
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
(NATURE PUBLISHING GROUP, 2015-06-04)Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia(1). ... -
The impact of the COVID-19 pandemic on patterns of attendance at emergency departments in two large London hospitals: an observational study.
(Springer Science and Business Media LLC, 2021-09-23)BACKGROUND: Hospitals in England have undergone considerable change to address the surge in demand imposed by the COVID-19 pandemic. The impact of this on emergency department (ED) attendances is unknown, especially for ... -
The Influence of Antireflux Surgery on Esophageal Cancer Risk in England: National Population-based Cohort Study.
(2018-11)Objective To evaluate how antireflux surgery influences the risk of esophageal cancer in patients with gastroesophageal reflux disease (GERD) and Barrett esophagus.Background GERD is a major risk factor for esophageal ... -
The internal dosimetry user group position statement on molecular radiotherapy.
(Oxford University Press (OUP), 2021-10-01)The Internal Dosimetry User Group (IDUG) is an independent, non-profit group of medical professionals dedicated to the promotion of dosimetry in molecular radiotherapy (www.IDUG.org.uk). The Ionising Radiation (Medical ... -
The Jun-dependent axon regeneration gene program: Jun promotes regeneration over plasticity.
(OXFORD UNIV PRESS, 2022-04-22)The regeneration-associated gene (RAG) expression program is activated in injured peripheral neurons after axotomy and enables long-distance axon re-growth. Over 1000 genes are regulated, and many transcription factors are ... -
The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.
(NATURE PUBLISHING GROUP, 2016-04-11)The Ku-binding motif (KBM) is a short peptide module first identified in APLF that we now show is also present in Werner syndrome protein (WRN) and in Modulator of retrovirus infection homologue (MRI). We also identify a ... -
The level of hypotension during hemorrhagic shock is a major determinant of the post-resuscitation systemic inflammatory response: an experimental study.
(Springer Science and Business Media LLC, 2008-07-18)BACKGROUND: To evaluate whether the level of hypotension during hemorrhagic shock may influence the oxidative and inflammatory responses developed during post-ischemic resuscitation. METHODS: Fifteen rabbits were equally ... -
The lung cancers: staging and response, CT, 18F-FDG PET/CT, MRI, DWI: review and new perspectives.
(BRITISH INST RADIOLOGY, 2023-08-01)Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer deaths in both sexes combined. Recent years have seen major advances in the diagnostic and treatment options for patients with non-small-cell ... -
The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.
(CELL PRESS, 2016-12-15)The Spindle Assembly Checkpoint (SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are attached to the spindle. It catalyzes the production of the Mitotic Checkpoint Complex ... -
The MOBSTER R package for tumour subclonal deconvolution from bulk DNA whole-genome sequencing data.
(BMC, 2020-11-17)BACKGROUND: The large-scale availability of whole-genome sequencing profiles from bulk DNA sequencing of cancer tissues is fueling the application of evolutionary theory to cancer. From a bulk biopsy, subclonal deconvolution ... -
The Noninvasive Ventilation Outcomes (NIVO) score: prediction of in-hospital mortality in exacerbations of COPD requiring assisted ventilation.
(EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2021-11-01)INTRODUCTION: Acute exacerbations of COPD (AECOPD) complicated by acute (acidaemic) hypercapnic respiratory failure (AHRF) requiring ventilation are common. When applied appropriately, ventilation substantially reduces ... -
The patient perspective in the era of personalized medicine: What about scanxiety?
Frequency of scanning has accelerated in the era of personalized medicine and is related, but not restricted, to the exploding number of clinical trials for new cancer treatments. Particularly in drug trials, but also in ... -
The risk-value trade-off: price and brand information impact consumers' intentions to purchase OTC drugs.
(2021-01-25)<h4>Background</h4>European countries face fiscal pressure regarding the long-term sustainability of their healthcare system due to increasing levels of public health expenditures and mounting demographic pressures. The ... -
The role of lifestyle characteristics on prostate cancer progression in two active surveillance cohorts.
(2016-09)Background Although much research has examined the relationship between lifestyle and prostate cancer (PCa) risk, few studies focus on the relationship between lifestyle and PCa progression. The present study examines this ... -
The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer.
(SOC NUCLEAR MEDICINE INC, 2023-07-01)Radioactive iodine is well established as a successful treatment for differentiated thyroid cancer (DTC), although around 15% of patients have local recurrence or develop distant metastases and may become refractory to ... -
The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma.
(SPRINGERNATURE, 2022-10-14)Intratumour heterogeneity (ITH) has become an important focus of cancer research in recent years. ITH describes the cellular variation that enables tumour evolution, including tumour progression, metastasis and resistance ... -
The safety and efficacy of radium-223 dichloride for the treatment of advanced prostate cancer.
(2016-09)Introduction A number of drugs have been shown to extend life expectancy in castration-resistant prostate cancer (CRPC). Skeletal related events (SREs) secondary to bone metastases cause significant morbidity for men with ...
