Browsing Other ICR Research by title
Now showing items 129-148 of 612
-
Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy in BRAF V600-mutant stage III melanoma after definitive surgery: a multicenter, retrospective cohort study.
(ELSEVIER, 2023-11-01)BACKGROUND: Both dabrafenib/trametinib (D/T) and anti-PD-1 monotherapy (PD-1) are approved adjuvant therapies for patients with stage III BRAF V600-mutant melanoma. However, there is still a lack of head-to-head comparative ... -
Dataset of prefrontal transcranial direct-current stimulation to improve early surgical knot-tying skills.
Transcranial direct-current stimulation (tDCS) has previously demonstrated promising effects in improving surgical performance with motor region stimulation [1], [2], [3], [4]. However, extensive prior research has revealed ... -
De-escalating Surgery Among Patients with HER2 + and Triple Negative Breast Cancer.
(SPRINGER, 2022-07-27)PURPOSE OF REVIEW: De-escalation of surgery has been central in the evolution of multidisciplinary management of breast cancer. Advances in oncology and increasing use of neoadjuvant chemotherapy (NACT) have opened ... -
Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
(BIOMED CENTRAL LTD, 2014)The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer ... -
Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias.
(AMER SOC CLINICAL INVESTIGATION INC, 2021-08-23)Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations in genes encoding proteins involved in centrosomal and chromosomal dynamics during mitosis. Detailed MCPH pathogenesis at the cellular ... -
Delayed APC/C activation extends the first mitosis of mouse embryos.
(Springer Science and Business Media LLC, 2017-08-29)The correct temporal regulation of mitosis underpins genomic stability because it ensures the alignment of chromosomes on the mitotic spindle that is required for their proper segregation to the two daughter cells. Crucially, ... -
A Delphi consensus statement for digital surgery.
(NATURE PORTFOLIO, 2022-07-19)The use of digital technology is increasing rapidly across surgical specialities, yet there is no consensus for the term 'digital surgery'. This is critical as digital health technologies present technical, governance, and ... -
Demonstration of correlations between clinical and physical image quality measures in chest and lumbar spine screen-film radiography
(BRITISH INST RADIOLOGY, 2001-06)The ability to predict clinical image quality from physical measures is useful for optimization in diagnostic radiology. In this work, clinical and physical assessments of image quality are compared and correlations between ... -
Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap
(2003-01)Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death, as evident ... -
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma.
(CELL PRESS, 2021-11-08)ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the mechanism ... -
Developing and testing a robotic MRI/CT fusion biopsy technique using a purpose-built interventional phantom.
(SPRINGER WIEN, 2022-11-22)BACKGROUND: Magnetic resonance imaging (MRI) can be used to target tumour components in biopsy procedures, while the ability to precisely correlate histology and MRI signal is crucial for imaging biomarker validation. ... -
Development and Evaluation of Machine Learning in Whole-Body Magnetic Resonance Imaging for Detecting Metastases in Patients With Lung or Colon Cancer: A Diagnostic Test Accuracy Study.
(LIPPINCOTT WILLIAMS & WILKINS, 2023-12-01)OBJECTIVES: Whole-body magnetic resonance imaging (WB-MRI) has been demonstrated to be efficient and cost-effective for cancer staging. The study aim was to develop a machine learning (ML) algorithm to improve radiologists' ... -
Development and results of a patient-reported treatment experience questionnaire on a 1.5 T MR-Linac.
(ELSEVIER IRELAND LTD, 2021-09-01)INTRODUCTION: With the implementation of new radiotherapy technology, it is imperative that patient experience is investigated alongside efficacy and outcomes. This paper presents the development of a specifically designed ... -
Development of an intervention to support the implementation of evidence-based strategies for optimising antibiotic prescribing in general practice.
(Springer Science and Business Media LLC, 2021-09-15)BACKGROUND: Trials show that antimicrobial stewardship (AMS) strategies, including communication skills training, point-of-care C-reactive protein testing (POC-CRPT) and delayed prescriptions, help optimise antibiotic ... -
Development of an online research platform for use in a large-scale multicentre study.
Background Participation in research can be beneficial for patients and healthcare providers, but may prove demanding at patient, clinician and organizational levels. Patient representatives are supportive of online research ... -
Development of chemical tool compounds targeting the non-catalytic functions of tankyrase
(Institute of Cancer Research (University Of London), 2023-06-16)Tankyrase (TNKS1 and TNKS2) is a promising target in anti-cancer drug discovery due to its role in regulating cellular processes which are dysregulated in cancer. In addition to catalysing the poly(ADP-ribosyl)ation of ... -
Development of novel therapeutic strategies in relapsed advanced/metastatic non-small cell lung cancer
(Institute of Cancer Research (University Of London), 2022-02-28)Recent advances in the treatment of advanced NSCLC include introduction of targeted therapies and immune-checkpoint inhibitors, leading to improvements in survival outcomes. However, significant new challenges and questions ... -
Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
(LIPPINCOTT WILLIAMS & WILKINS, 2022-05-01)BACKGROUND AND OBJECTIVES: Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare disorder of the nervous system that classically presents with a combination of characteristic eye movement disorder and myoclonus, in addition ... -
Diagnostic accuracy of deep learning in medical imaging: a systematic review and meta-analysis.
(2021-04-07)Deep learning (DL) has the potential to transform medical diagnostics. However, the diagnostic accuracy of DL is uncertain. Our aim was to evaluate the diagnostic accuracy of DL algorithms to identify pathology in medical ...
