Now showing items 1-3 of 3

    • Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis. 

      Yeung, ATY; Hale, C; Lee, AH; Gill, EE; Bushell, W; Parry-Smith, D; Goulding, D; Pickard, D; Roumeliotis, T; Choudhary, J; Thomson, N; Skarnes, WC; Dougan, G; Hancock, REW (2017-04-25)
      Chlamydia trachomatis remains a leading cause of bacterial sexually transmitted infections and preventable blindness worldwide. There are, however, limited in vitro models to study the role of host genetics in the response ...
    • Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer. 

      Evans, R; Flores-Borja, F; Nassiri, S; Miranda, E; Lawler, K; Grigoriadis, A; Monypenny, J; Gillet, C; Owen, J; Gordon, P; Male, V; Cheung, A; Noor, F; Barber, P; Marlow, R; Francesch-Domenech, E; Fruhwirth, G; Squadrito, M; Vojnovic, B; Tutt, A; Festy, F; De Palma, M; Ng, T (2019-05)
      Lymphatic vasculature is crucial for metastasis in triple-negative breast cancer (TNBC); however, cellular and molecular drivers controlling lymphovascular metastasis are poorly understood. We define a macrophage-dependent ...
    • Pan-cancer deconvolution of tumour composition using DNA methylation. 

      Chakravarthy, A; Furness, A; Joshi, K; Ghorani, E; Ford, K; Ward, MJ; King, EV; Lechner, M; Marafioti, T; Quezada, SA; Thomas, GJ; Feber, A; Fenton, TR (2018-08-13)
      The nature and extent of immune cell infiltration into solid tumours are key determinants of therapeutic response. Here, using a DNA methylation-based approach to tumour cell fraction deconvolution, we report the integrated ...