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Advances in the Pathology and Molecular Biology of Sarcomas and the Impact on Treatment.

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Date
2017-08
ICR Author
Fisher, Cyril
Thway, Khin
Jones, Robin
Marsden,
Author
Thway, K
Noujaim, J
Jones, RL
Fisher, C
Type
Journal Article
Metadata
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Abstract
Sarcomas are a complex group of childhood and adult neoplasms with differentiation towards mesenchymal tissues that can occur at almost every anatomic site. Although pathologically diverse, they frequently show similar clinical presentations and radiological findings, such that correct histopathologic diagnosis, utilising the appropriate ancillary immunohistochemical and molecular techniques, underpins their management. This article gives an overview of the pathology, coupled with recent advances in molecular biology, of a selection of soft tissue sarcomas from a clinicopathological perspective, discussing histopathological diagnosis with developments in molecular diagnosis and the incorporation of these findings into diagnostic practice and current and potential targeted treatments.
URI
https://repository.icr.ac.uk/handle/internal/1118
DOI
https://doi.org/10.1016/j.clon.2017.02.010
Collections
  • Clinical Studies
Subject
Humans
Sarcoma
Adult
Research team
Sarcoma Clinical Trials (R Jones)
Language
eng
Date accepted
2017-02-14
License start date
2017-08
Citation
Clinical oncology (Royal College of Radiologists (Great Britain)), 2017, 29 (8), pp. 471 - 480

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