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dc.contributor.authorRyan, CJ
dc.contributor.authorKennedy, S
dc.contributor.authorBajrami, I
dc.contributor.authorMatallanas, D
dc.contributor.authorLord, CJ
dc.date.accessioned2018-02-15T15:10:46Z
dc.date.issued2017-10-11
dc.identifier.citationCell systems, 2017, 5 (4), pp. 399 - 409.e5
dc.identifier.issn2405-4712
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1131
dc.identifier.eissn2405-4720
dc.identifier.doi10.1016/j.cels.2017.09.011
dc.description.abstractProtein complexes are responsible for the bulk of activities within the cell, but how their behavior and abundance varies across tumors remains poorly understood. By combining proteomic profiles of breast tumors with a large-scale protein-protein interaction network, we have identified a set of 285 high-confidence protein complexes whose subunits have highly correlated protein abundance across tumor samples. We used this set to identify complexes that are reproducibly under- or overexpressed in specific breast cancer subtypes. We found that mutation or deletion of one subunit of a co-regulated complex was often associated with a collateral reduction in protein expression of additional complex members. This collateral loss phenomenon was typically evident from proteomic, but not transcriptomic, profiles, suggesting post-transcriptional control. Mutation of the tumor suppressor E-cadherin (CDH1) was associated with a collateral loss of members of the adherens junction complex, an effect we validated using an engineered model of E-cadherin loss.
dc.formatPrint-Electronic
dc.format.extent399 - 409.e5
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectCell Line, Tumor
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectCadherins
dc.subjectProteome
dc.subjectProteomics
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectRNA Processing, Post-Transcriptional
dc.subjectMutation
dc.subjectGenes, Tumor Suppressor
dc.subjectFemale
dc.subjectProtein Interaction Maps
dc.subjectMCF-7 Cells
dc.titleA Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.
dc.typeJournal Article
dcterms.dateAccepted2017-09-18
rioxxterms.versionofrecord10.1016/j.cels.2017.09.011
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-10-11
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCell systems
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.publication-statusPublished
pubs.volume5
pubs.embargo.termsNot known
icr.researchteamGene Functionen_US
dc.contributor.icrauthorLord, Christopheren


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