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dc.contributor.authorCeriani, Len_US
dc.contributor.authorMartelli, Men_US
dc.contributor.authorGospodarowicz, MKen_US
dc.contributor.authorRicardi, Uen_US
dc.contributor.authorFerreri, AJMen_US
dc.contributor.authorChiappella, Aen_US
dc.contributor.authorStelitano, Cen_US
dc.contributor.authorBalzarotti, Men_US
dc.contributor.authorCabrera, MEen_US
dc.contributor.authorCunningham, Den_US
dc.contributor.authorGuarini, Aen_US
dc.contributor.authorZinzani, PLen_US
dc.contributor.authorGiovanella, Len_US
dc.contributor.authorJohnson, PWMen_US
dc.contributor.authorZucca, Een_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2018-02-16T09:30:03Z
dc.date.issued2017-01-01en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/27839910en_US
dc.identifierS0360-3016(16)33242-4en_US
dc.identifier.citationInt J Radiat Oncol Biol Phys, 2017, 97 (1), pp. 42 - 49en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1151
dc.identifier.eissn1879-355Xen_US
dc.identifier.doi10.1016/j.ijrobp.2016.09.031en_US
dc.description.abstractPURPOSE: To assess the predictive value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for disease recurrence after immunochemotherapy (R-CHT) and mediastinal irradiation (RT), using the recently published criteria of the Lugano classification to predict outcomes for patients with primary mediastinal large B-cell lymphoma. METHODS AND MATERIALS: Among 125 patients prospectively enrolled in the IELSG-26 study, 88 were eligible for central review of PET/CT scans after completion of RT. Responses were evaluated using the 5-point Deauville scale at the end of induction R-CHT and after consolidation RT. According to the Lugano classification, a complete metabolic response (CMR) was defined by a Deauville score (DS) ≤3. RESULTS: The CMR (DS1, -2, or -3) rate increased from 74% (65 patients) after R-CHT to 89% (78 patients) after consolidation RT. Among the 10 patients (11%) with persistently positive scans, the residual uptake after RT was slightly higher than the liver uptake in 6 patients (DS4; 7%) and markedly higher in 4 patients (DS5; 4%): these patients had a significantly poorer 5-year progression-free survival and overall survival. At a median follow-up of 60 months (range, 35-107 months), no patients with a CMR after RT have relapsed. Among the 10 patients who did not reach a CMR, 3 of the 4 patients (positive predictive value, 75%) with DS5 after RT had subsequent disease progression (within the RT volume in all cases) and died. All patients with DS4 had good outcomes without recurrence. CONCLUSIONS: All the patients obtaining a CMR defined as DS ≤3 remained progression-free at 5 years, confirming the excellent negative predictive value of the Lugano classification criteria in primary mediastinal large B-cell lymphoma patients. The few patients with DS4 also had an excellent outcome, suggesting that they do not necessarily require additional therapy, because the residual 18F-fluorodeoxyglucose uptake may not reflect persistent lymphoma.en_US
dc.format.extent42 - 49en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectAdulten_US
dc.subjectAntineoplastic Combined Chemotherapy Protocolsen_US
dc.subjectBleomycinen_US
dc.subjectCyclophosphamideen_US
dc.subjectDisease Progressionen_US
dc.subjectDisease-Free Survivalen_US
dc.subjectDoxorubicinen_US
dc.subjectEtoposideen_US
dc.subjectFemaleen_US
dc.subjectFluorodeoxyglucose F18en_US
dc.subjectHumansen_US
dc.subjectImmunotherapyen_US
dc.subjectLeucovorinen_US
dc.subjectLiveren_US
dc.subjectLymphoma, B-Cellen_US
dc.subjectMaleen_US
dc.subjectMediastinal Neoplasmsen_US
dc.subjectMethotrexateen_US
dc.subjectNeoplasm, Residualen_US
dc.subjectPositron Emission Tomography Computed Tomographyen_US
dc.subjectPrednisoneen_US
dc.subjectProspective Studiesen_US
dc.subjectRadiopharmaceuticalsen_US
dc.subjectRadiotherapy Dosageen_US
dc.subjectRadiotherapy, Conformalen_US
dc.subjectRecurrenceen_US
dc.subjectRituximaben_US
dc.subjectStatistics, Nonparametricen_US
dc.subjectVincristineen_US
dc.subjectYoung Adulten_US
dc.titlePositron Emission Tomography/Computed Tomography Assessment After Immunochemotherapy and Irradiation Using the Lugano Classification Criteria in the IELSG-26 Study of Primary Mediastinal B-Cell Lymphoma.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-09-21en_US
rioxxterms.versionofrecord10.1016/j.ijrobp.2016.09.031en_US
rioxxterms.licenseref.startdate2017-01-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfInt J Radiat Oncol Biol Physen_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume97en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMedicine (RMH Smith Cunningham)en_US
dc.contributor.icrauthorCunningham, Daviden_US
dc.contributor.icrauthorMarsden,en_US


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