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dc.contributor.authorGough, Nen_US
dc.contributor.authorKoffman, Jen_US
dc.contributor.authorRoss, JRen_US
dc.contributor.authorRiley, Jen_US
dc.contributor.authorJudson, Ien_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2018-02-16T09:30:20Z
dc.date.issued2017-03en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28042077en_US
dc.identifierS0885-3924(16)31194-0en_US
dc.identifier.citationJ Pain Symptom Manage, 2017, 53 (3), pp. 588 - 597en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1153
dc.identifier.eissn1873-6513en_US
dc.identifier.doi10.1016/j.jpainsymman.2016.10.357en_US
dc.description.abstractCONTEXT: There is little information on symptom prevalence and severity in advanced soft-tissue sarcoma (STS). Understanding symptom burden will aid clinical consultations, clarify which symptom interventions are needed, and better define optimum timings of palliative and supportive care referrals. OBJECTIVES: To describe symptom prevalence and severity in patients undergoing different treatment options for advanced STS: 1) first-line palliative chemotherapy (FLC), 2) active surveillance (AS) pre- and post-FLC, and 3) palliative care (PC) alone. METHODS: Cross-sectional survey in one sarcoma center using the patient-reported Memorial Symptom Assessment Scale-Short Form (MSAS-SF). Symptom prevalence, severity, and MSAS-SF subscales were recorded before commencing a new treatment. Our results were compared with other MSAS-SF cancer and noncancer data. RESULTS: One-hundred and thirteen patients (mean age, 59 years) were recruited. Forty-two commenced FLC, 27 started AS pre-FLC, 24 AS post-FLC, and 20 PC alone. Median overall number of reported symptoms was 11 (range 1-31): which when stratified by treatment meant AS pre-FLC < AS post-FLC < FLC < PC alone (most symptomatic). The commonest physical symptoms were pain (77%; 95% CI 68-84), lack of energy (73%; CI 63-81) difficulty sleeping (56%; CI 46-65), feeling bloated (49%; CI 39-58), and dyspnea (49%; CI 39-58). Distress levels were commensurated with prevalence except for dyspnea, which was disproportionally less distressing. Psychological distress was moderate (mean MSAS-PSYCH: 1.39) but higher than comparative cancer data. CONCLUSION: Advanced STS patients have a clinically important symptom burden comparable to other cancers. Common symptoms should be screened and addressed appropriately, including timely PC involvement.en_US
dc.format.extent588 - 597en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectAdvanced soft-tissue sarcomaen_US
dc.subjectcanceren_US
dc.subjectpalliative careen_US
dc.subjectprevalence studyen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectCost of Illnessen_US
dc.subjectCross-Sectional Studiesen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPalliative Careen_US
dc.subjectPatient Reported Outcome Measuresen_US
dc.subjectPrevalenceen_US
dc.subjectSarcomaen_US
dc.subjectSeverity of Illness Indexen_US
dc.titleSymptom Burden in Advanced Soft-Tissue Sarcoma.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-10-07en_US
rioxxterms.versionofrecord10.1016/j.jpainsymman.2016.10.357en_US
rioxxterms.licenseref.startdate2017-03en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfJ Pain Symptom Manageen_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume53en_US
pubs.embargo.termsNot knownen_US
icr.researchteamSarcoma Clinical Trialsen_US
dc.contributor.icrauthorJudson, Ianen_US
dc.contributor.icrauthorMarsden,en_US


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