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dc.contributor.authorLim Joon, D
dc.contributor.authorLim, A
dc.contributor.authorSchneider, M
dc.contributor.authorHiew, C-Y
dc.contributor.authorLawrentschuk, N
dc.contributor.authorSengupta, S
dc.contributor.authorForoudi, F
dc.contributor.authorJenkins, T
dc.contributor.authorAngus, D
dc.contributor.authorWada, M
dc.contributor.authorChao, M
dc.contributor.authorKhoo, V
dc.date.accessioned2018-02-16T10:14:40Z
dc.date.issued2017-10
dc.identifier.citationRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017, 125 (1), pp. 113 - 117
dc.identifier.issn0167-8140
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1167
dc.identifier.eissn1879-0887
dc.identifier.doi10.1016/j.radonc.2017.08.031
dc.description.abstractBackground Vesico-urethral anastomosis (VUA) is critical to the clinical target volume (CTV) in post-prostatectomy radiotherapy (PPRT), as it is the commonest site of recurrence. Typically, this is performed on a CT alone but guidelines recommend MRI.Objective To evaluate the VUA spatial differences between CT (ctVUA) and MRI (mrVUA) and analyse its impact on the CT defined CTV (ctCTV) as recommended by published guidelines.Materials and methods We identified 34 patients with a co-registered simulation CT and T2 weighted MRI. The VUA was located on CT and MRI whilst blinded to the opposing scan. The differences were analysed using Wilcoxon's Signed Rank Test. The mrVUA coverage was investigated using three ctCTV margins of 5mm, 8mm and 12mm.Results Median age was 63years with 59% having pT3a disease and median Gleason score of 7. The mrVUA was coincident with the ctVUA in 12% and inferior in 88%. Median difference was 5mm (0-10mm) (P<0.0001). Only a ctCTV margin of 12mm would have encompassed all mrVUAs. A ctCTV margin of 8mm and 5mm resulted in 12% and 38% cases where the VUA was excluded from the ctCTV.Conclusions MRI is important for the accurate delineation of VUA for PPRT.
dc.formatPrint-Electronic
dc.format.extent113 - 117
dc.languageeng
dc.language.isoeng
dc.subjectUrethra
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectNeoplasm Recurrence, Local
dc.subjectTomography, X-Ray Computed
dc.subjectMagnetic Resonance Imaging
dc.subjectNeoplasm Staging
dc.subjectRadiotherapy Planning, Computer-Assisted
dc.subjectAnastomosis, Surgical
dc.subjectProstatectomy
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectUrinary Bladder
dc.titleProstate cancer post-prostatectomy radiotherapy: CT vs MRI for vesico-urethral anastomosis target delineation.
dc.typeJournal Article
dcterms.dateAccepted2017-08-16
rioxxterms.versionofrecord10.1016/j.radonc.2017.08.031
rioxxterms.licenseref.startdate2017-10
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume125
pubs.embargo.termsNot known
dc.contributor.icrauthorMarsden,en


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