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dc.contributor.authorZhang, AY
dc.contributor.authorJudson, I
dc.contributor.authorBenson, C
dc.contributor.authorWunder, JS
dc.contributor.authorRay-Coquard, I
dc.contributor.authorGrimer, RJ
dc.contributor.authorQuek, R
dc.contributor.authorWong, E
dc.contributor.authorMiah, AB
dc.contributor.authorFerguson, PC
dc.contributor.authorDufresne, A
dc.contributor.authorTeh, JYH
dc.contributor.authorStockler, M
dc.contributor.authorTattersall, MHN
dc.date.accessioned2018-02-16T10:48:23Z
dc.date.issued2017-07
dc.identifier.citationBritish journal of cancer, 2017, 117 (3), pp. 326 - 331
dc.identifier.issn0007-0920
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1189
dc.identifier.eissn1532-1827
dc.identifier.doi10.1038/bjc.2017.198
dc.description.abstractBackground An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association.Methods This was a retrospective cohort study of RIS cases across five large international sarcoma centres between 1 January 2000 to 31 December 2014. The primary endpoint was time to development of RIS.Results We identified 419 patients with RIS. Chemotherapy for the first malignancy was associated with a shorter time to RIS development (HR 1.37; 95% CI: 1.08-1.72; P=0.009). In the multi-variable model, older age (HR 2.11; 95% CI 1.83-2.43; P<0.001) and chemotherapy for the first malignancy (HR 1.61; 95% CI 1.26-2.05; P<0·001) were independently associated with a shorter time to RIS. Anthracyclines and alkylating agents significantly contribute to the effect.Conclusions This study confirms an association between chemotherapy given for the first malignancy and a shorter time to development of RIS.
dc.formatPrint-Electronic
dc.format.extent326 - 331
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectSarcoma
dc.subjectNeoplasms, Radiation-Induced
dc.subjectNeoplasms, Second Primary
dc.subjectAnthracyclines
dc.subjectAntineoplastic Agents
dc.subjectAntineoplastic Agents, Alkylating
dc.subjectRetrospective Studies
dc.subjectAge Factors
dc.subjectTime Factors
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectInfant
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.titleChemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study.
dc.typeJournal Article
dcterms.dateAccepted2017-06-05
rioxxterms.versionofrecord10.1038/bjc.2017.198
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
rioxxterms.licenseref.startdate2017-07
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBritish journal of cancer
pubs.issue3
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume117
pubs.embargo.termsNot known
icr.researchteamSarcoma Clinical Trialsen_US
dc.contributor.icrauthorMiah, Aishaen
dc.contributor.icrauthorJudson, Ianen
dc.contributor.icrauthorMarsden,en


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