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dc.contributor.authorCardoso, Fen_US
dc.contributor.authorHarbeck, Nen_US
dc.contributor.authorBarrios, CHen_US
dc.contributor.authorBergh, Jen_US
dc.contributor.authorCortés, Jen_US
dc.contributor.authorEl Saghir, Nen_US
dc.contributor.authorFrancis, PAen_US
dc.contributor.authorHudis, CAen_US
dc.contributor.authorOhno, Sen_US
dc.contributor.authorPartridge, AHen_US
dc.contributor.authorSledge, GWen_US
dc.contributor.authorSmith, IEen_US
dc.contributor.authorGelmon, KAen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2018-02-16T11:39:45Z
dc.date.issued2017-02-01en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/27831505en_US
dc.identifiermdw571en_US
dc.identifier.citationAnn Oncol, 2017, 28 (2), pp. 208 - 217en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1193
dc.identifier.eissn1569-8041en_US
dc.identifier.doi10.1093/annonc/mdw571en_US
dc.description.abstractNew research questions emerge as medical needs continue to evolve and as we improve our understanding of cancer biology and treatment of malignancies. Although significant advances have been made in some areas of breast cancer research resulting in improvements in therapies and outcomes over the last few decades, other areas have not benefited to the same degree and we continue to have many gaps in our knowledge. This article summarizes the 12 short and medium-term clinical research needs in breast cancer deemed as priorities in 2016 by a panel of experts, in an attempt to focus and accelerate future research in the most needed areas: (i) de-escalate breast cancer therapies in early breast cancer without sacrificing outcomes; (ii) explore optimal adjuvant treatment durations; (iii) develop better tools and strategies to identify patients with genetic predisposition; (iv) improve care in young patients with breast cancer; (v) develop tools to speed up drug development in biomarker-defined populations; (vi) identify and validate targets that mediate resistance to chemotherapy, endocrine therapy and anti-HER2 therapies; (vii) evaluate the efficacy of local-regional treatments for metastatic disease; (viii) better define the optimal sequence of treatments in the metastatic setting; (ix) evaluate the clinical impact of intra-patient heterogeneity (intra-tumor, inter-tumor and inter-lesion heterogeneity); (x) better understand the biology and identify new targets in triple-negative breast cancer; (xi) better understand immune surveillance in breast cancer and further develop immunotherapies; and (xii) increase survivorship research efforts including supportive care and quality of life.en_US
dc.format.extent208 - 217en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectbreast canceren_US
dc.subjectclinical researchen_US
dc.subjectmedical needsen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectBiomarkers, Tumoren_US
dc.subjectBiomedical Researchen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectDrug Resistance, Neoplasmen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMolecular Targeted Therapyen_US
dc.subjectQuality Improvementen_US
dc.subjectTreatment Outcomeen_US
dc.titleResearch needs in breast cancer.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1093/annonc/mdw571en_US
rioxxterms.licenseref.startdate2017-02-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfAnn Oncolen_US
pubs.issue2en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume28en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMedicine (RMH Smith Cunningham)en_US
dc.contributor.icrauthorSmith, Ianen_US
dc.contributor.icrauthorMarsden,en_US


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