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dc.contributor.authorYap, TA
dc.contributor.authorAerts, JG
dc.contributor.authorPopat, S
dc.contributor.authorFennell, DA
dc.date.accessioned2018-02-16T11:40:11Z
dc.date.issued2017-07
dc.identifier.citationNature reviews. Cancer, 2017, 17 (8), pp. 475 - 488
dc.identifier.issn1474-175X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1195
dc.identifier.eissn1474-1768
dc.identifier.doi10.1038/nrc.2017.42
dc.description.abstractMalignant mesothelioma is a universally lethal cancer that is increasing in incidence worldwide. There is a dearth of effective therapies, with only one treatment (pemetrexed and cisplatin combination chemotherapy) approved in the past 13 years. However, the past 5 years have witnessed an exponential growth in our understanding of mesothelioma pathobiology, which is set to revolutionize therapeutic strategies. From a genomic standpoint, mesothelioma is characterized by a preponderance of tumour suppressor alterations, for which novel therapies are currently in development. Other promising antitumour agents include inhibitors against angiogenesis, mesothelin and immune checkpoints, which are at various phases of clinical trial testing.
dc.formatPrint
dc.format.extent475 - 488
dc.languageeng
dc.language.isoeng
dc.subjectAnimals
dc.subjectHumans
dc.subjectMesothelioma
dc.subjectNeovascularization, Pathologic
dc.subjectUbiquitin Thiolesterase
dc.subjectTumor Suppressor Proteins
dc.subjectAntineoplastic Agents
dc.subjectAntibodies, Monoclonal
dc.subjectImmunotherapy
dc.subjectGenes, Tumor Suppressor
dc.subjectGenes, Neurofibromatosis 2
dc.subjectGenes, p16
dc.subjectProto-Oncogene Proteins c-akt
dc.subjectProtein-Arginine N-Methyltransferases
dc.subjectTOR Serine-Threonine Kinases
dc.subjectGPI-Linked Proteins
dc.subjectTumor Microenvironment
dc.subjectPhosphoinositide-3 Kinase Inhibitors
dc.titleNovel insights into mesothelioma biology and implications for therapy.
dc.typeJournal Article
rioxxterms.versionofrecord10.1038/nrc.2017.42
rioxxterms.licenseref.startdate2017-07
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature reviews. Cancer
pubs.issue8
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicine Drug Development Unit (de Bono)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine Drug Development Unit (de Bono)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology/Thoracic Oncology (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicine Drug Development Unit (de Bono)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine Drug Development Unit (de Bono)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology/Thoracic Oncology (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume17
pubs.embargo.termsNot known
icr.researchteamMedicine Drug Development Unit (de Bono)en_US
icr.researchteamThoracic Oncologyen_US
dc.contributor.icrauthorYap, Timothyen
dc.contributor.icrauthorPopat, Sanjayen
dc.contributor.icrauthorMarsden,en


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