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Recommendations on managing lenvatinib and everolimus in patients with advanced or metastatic renal cell carcinoma.

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Date
2017-12
ICR Author
Larkin, James
Marsden,
Author
Grande, E
Glen, H
Aller, J
Argenziano, G
Lamas, MJ
Ruszniewski, P
Zamorano, JL
Edmonds, K
Sarker, S
Staehler, M
Larkin, J
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Type
Journal Article
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Abstract
Introduction There are several second-line treatment options for patients with renal cell carcinoma after first-line failure of a tyrosine kinase inhibitor, especially with the recent approvals of cabozantinib, nivolumab, and the lenvatinib plus everolimus combination. A lack of reliable biomarkers and an overall lack of prospective head-to-head comparisons make it a challenge to choose a second-line treatment in the clinic. Areas covered: In this review/meta-opinion, we describe the safety profile of the lenvatinib plus everolimus combination in renal cell carcinoma. The combination of lenvatinib plus everolimus has achieved the highest rates of objective responses and the longest progression free and overall survival in cross-comparison trials. At the same time, the safety profile of this combination, including the rate of total and severe adverse events, the percentage of dose reductions required, and the rate of treatment discontinuation, was less favorable compared with available monotherapy options, suggesting that better management could help to maximize the activity of this combination while protecting patients from undue harm. Expert opinion: Herein, we aim to postulate multidisciplinary recommendations on the advice to offer to patients and caregivers before starting treatment and how to manage the combination from the perspective of daily clinical practice.
URI
https://repository.icr.ac.uk/handle/internal/1211
DOI
https://doi.org/10.1080/14740338.2017.1380624
Collections
  • Clinical Studies
Subject
Humans
Carcinoma, Renal Cell
Kidney Neoplasms
Phenylurea Compounds
Quinolines
Antineoplastic Combined Chemotherapy Protocols
Disease-Free Survival
Survival Rate
Dose-Response Relationship, Drug
Everolimus
Research team
Melanoma and Kidney Cancer
Language
eng
License start date
2017-12
Citation
Expert opinion on drug safety, 2017, 16 (12), pp. 1413 - 1426

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