The role of Cediranib in ovarian cancer.

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Publication Date
2017-10Author
Orbegoso, C
Marquina, G
George, A
Banerjee, S
Type
Journal Article
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Show full item recordAbstract
<h4>Introduction</h4>Treatment options for relapsed ovarian cancer have increased over the decade with the addition of targeted agents, such as PARP inhibitors and antiangiogenic agents. Bevacizumab, a monoclonal antibody binding vascular endothelial growth factor (VEGF), was the first anti-angiogenic agent to be incorporated in the ovarian cancer treatment landscape. Other molecules utilising different mechanisms of action to target angiogenesis have been developed, including cediranib, an oral potent inhibitor of VEGF Tyrosine Kinase Inhibitor that has demonstrated activity in both phase II and phase III studies. Areas covered: Herein we will review cediranib as well as the evidence for its use in ovarian cancer, both as monotherapy and in combination with chemotherapy, PARP inhibitors and immunotherapy. A literature search was made in PubMed and on ClinicalTrials.gov for clinical trials with cediranib. Expert opinion: The addition of cediranib for the treatment of ovarian cancer is promising, and has demonstrated a significant improvement in progression free survival in a phase III trial in combination with chemotherapy and maintenance treatment. Cediranib is currently being explored in ovarian cancer and other gynaecological malignancies aiming to improve patient care; further research will help define its role in standard clinical practice for patients with ovarian cancer.
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Subject
Animals
Humans
Ovarian Neoplasms
Quinazolines
Angiogenesis Inhibitors
Antineoplastic Combined Chemotherapy Protocols
Disease-Free Survival
Combined Modality Therapy
Drug Evaluation, Preclinical
Female
Clinical Trials, Phase III as Topic
Language
eng
License start date
2017-10
Citation
Expert opinion on pharmacotherapy, 2017, 18 (15), pp. 1637 - 1648