Show simple item record

dc.contributor.authorQiu, S
dc.contributor.authorPellino, G
dc.contributor.authorFiorentino, F
dc.contributor.authorRasheed, S
dc.contributor.authorDarzi, A
dc.contributor.authorTekkis, P
dc.contributor.authorKontovounisios, C
dc.date.accessioned2018-02-19T10:59:06Z
dc.date.issued2017-01
dc.identifier.citationGastroenterology research and practice, 2017, 2017 pp. 6456257 - ?
dc.identifier.issn1687-6121
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1260
dc.identifier.eissn1687-630X
dc.identifier.doi10.1155/2017/6456257
dc.description.abstractNeurotensin (NTS) is a physiologically occurring hormone which affects the function of the gastrointestinal (GI) tract. In recent years, NTS, acting through its cellular receptors (NTSR), has been implicated in the carcinogenesis of several cancers. In colorectal cancer (CRC), a significant body of evidence, from in vitro and in vivo studies, is available which elucidates the molecular biology of NTS/NTSR signalling and the resultant growth of CRC cells. There is growing clinical data from human studies which corroborate the role NTS/NTSR plays in the development of human CRC. Furthermore, blockade and modulation of the NTS/NTSR signalling pathways appears to reduce CRC growth in cell cultures and animal studies. Lastly, NTS/NTSR also shows potential of being utilised as a diagnostic biomarker for cancers as well as targets for functional imaging. We summarise the existing evidence and understanding of the role of NTS and its receptors in CRC.
dc.formatPrint-Electronic
dc.format.extent6456257 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleA Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer.
dc.typeJournal Article
dcterms.dateAccepted2017-01-24
rioxxterms.versionofrecord10.1155/2017/6456257
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfGastroenterology research and practice
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume2017
pubs.embargo.termsNot known
dc.contributor.icrauthorDarzi, Araen
dc.contributor.icrauthorMarsden,en


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0