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dc.contributor.authorHallin, M
dc.contributor.authorMudan, S
dc.contributor.authorThway, K
dc.date.accessioned2018-02-19T11:06:30Z
dc.date.issued2017-02
dc.identifier.citationInternational journal of surgical pathology, 2017, 25 (1), pp. 51 - 53
dc.identifier.issn1066-8969
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1270
dc.identifier.eissn1940-2465
dc.identifier.doi10.1177/1066896916660197
dc.description.abstractGastrointestinal stromal tumors (GISTs) are potentially aggressive mesenchymal neoplasms with spindle cell, epithelioid, or mixed morphology. They typically express CD117, DOG1, and CD34 and can be diffusely and strongly positive for h-caldesmon. Leiomyomas are benign smooth muscle neoplasms that can arise in a variety of visceral and soft tissue sites, including the gastrointestinal tract. We illustrate a case of a neoplasm of the gastroesophageal junction that was clinically suspected to be a GIST. Histology showed a tumor composed of ovoid and spindle cells arranged in short intersecting fascicles, which was positive for desmin, smooth muscle actin, and h-caldesmon, with a prominent interspersed subpopulation of CD117- and DOG1-positive elongated or dendritic-like cells. These features were of leiomyoma with entrapped interstitial cells of Cajal (ICC). The recognition of possible entrapment of ICC in leiomyomas as a potential mimic of GIST is important for correct treatment and prognostication.
dc.formatPrint-Electronic
dc.format.extent51 - 53
dc.languageeng
dc.language.isoeng
dc.subjectHumans
dc.subjectLeiomyoma
dc.subjectEsophageal Neoplasms
dc.subjectGastrointestinal Stromal Tumors
dc.subjectDiagnosis, Differential
dc.subjectImmunohistochemistry
dc.subjectInterstitial Cells of Cajal
dc.subjectBiomarkers, Tumor
dc.titleInterstitial Cells of Cajal in Deep Esophageal Leiomyoma.
dc.typeJournal Article
rioxxterms.versionofrecord10.1177/1066896916660197
rioxxterms.licenseref.startdate2017-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfInternational journal of surgical pathology
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume25
pubs.embargo.termsNot known
dc.contributor.icrauthorThway, Khinen
dc.contributor.icrauthorMarsden,en


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