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Metastatic Sclerosing Epithelioid Fibrosarcoma in Bone Marrow.

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Publication Date
2017-12
ICR Author
Zaidi, Shane Haider
Thway, Khin
Marsden,
Author
Asakra, R
Zaidi, S
Thway, K
Type
Journal Article
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Abstract
Sclerosing epithelioid fibrosarcoma (SEF) is an aggressive neoplasm thought to be related to low-grade fibromyxoid sarcoma, which typically occurs in middle-aged adults in the deep soft tissues of the lower extremities and trunk. It comprises nests and cords of relatively uniform epithelioid polygonal cells with clear or eosinophilic cytoplasm in densely sclerotic stroma, and it is typically associated with EWSR1 gene rearrangements, and most commonly EWSR1-CREB3L1 fusions. As primary SEF can arise in bone, and bone is also a common metastatic site for SEF, its recognition at this site is important. We illustrate bone marrow showing diffuse infiltration by SEF and highlight the potential for confusion with a range of neoplasms such as carcinoma, hematolymphoid neoplasms, and other sarcomas.
URL
https://repository.icr.ac.uk/handle/internal/1274
Collections
  • Cancer Biology
  • Radiotherapy and Imaging
Version of record
10.1177/1066896917720727
Subject
Abdominal Wall
Epithelioid Cells
Humans
Fibrosarcoma
Sarcoma
Bone Marrow Neoplasms
Soft Tissue Neoplasms
Diagnosis, Differential
Research team
Targeted Therapy
Language
eng
License start date
2017-12
Citation
International journal of surgical pathology, 2017, 25 (8), pp. 702 - 704

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