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dc.contributor.authorMiki, Y
dc.contributor.authorThway, K
dc.date.accessioned2018-02-19T11:08:53Z
dc.date.issued2017-06
dc.identifier.citationInternational journal of surgical pathology, 2017, 25 (4), pp. 310 - 313
dc.identifier.issn1066-8969
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1276
dc.identifier.eissn1940-2465
dc.identifier.doi10.1177/1066896917696749
dc.description.abstractMalignant peripheral nerve sheath tumors (MPNST) are soft tissue neoplasms with evidence of nerve sheath differentiation. They usually arise from peripheral nerves or from preexisting benign nerve sheath neoplasms, often in patients with neurofibromatosis type 1 (NF1). The histologic diagnosis of MPNST is challenging as their morphology is highly variable, and there has been a lack of routine diagnostic immunohistochemical markers and specific genetic aberrations. Although divergent differentiation is well documented in MPNST, it is most frequently toward mesenchymal elements. Differentiation toward epithelial elements is very rare, and we illustrate a case of MPNST with glandular differentiation, comprising prominent well-formed glands, with a brief discussion of biphasic (spindle and glandular) neoplasms in the differential diagnosis. An index of suspicion for MPNST is necessary, due to the differing management from tumors in its differential diagnosis, and because of the potential for therapies toward molecular targets in future.
dc.formatPrint-Electronic
dc.format.extent310 - 313
dc.languageeng
dc.language.isoeng
dc.subjectHumans
dc.subjectNeurilemmoma
dc.subjectSoft Tissue Neoplasms
dc.subjectNeoplasm Recurrence, Local
dc.titleMalignant Peripheral Nerve Sheath Tumor With Divergent Glandular Differentiation.
dc.typeJournal Article
rioxxterms.versionofrecord10.1177/1066896917696749
rioxxterms.licenseref.startdate2017-06
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfInternational journal of surgical pathology
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume25
pubs.embargo.termsNot known
dc.contributor.icrauthorThway, Khinen
dc.contributor.icrauthorMarsden,en


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