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dc.contributor.authorMiki, Yen_US
dc.contributor.authorThway, Ken_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2018-02-19T11:08:53Z
dc.date.issued2017-06en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28381143en_US
dc.identifier.citationInt J Surg Pathol, 2017, 25 (4), pp. 310 - 313en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1276
dc.identifier.eissn1940-2465en_US
dc.identifier.doi10.1177/1066896917696749en_US
dc.description.abstractMalignant peripheral nerve sheath tumors (MPNST) are soft tissue neoplasms with evidence of nerve sheath differentiation. They usually arise from peripheral nerves or from preexisting benign nerve sheath neoplasms, often in patients with neurofibromatosis type 1 (NF1). The histologic diagnosis of MPNST is challenging as their morphology is highly variable, and there has been a lack of routine diagnostic immunohistochemical markers and specific genetic aberrations. Although divergent differentiation is well documented in MPNST, it is most frequently toward mesenchymal elements. Differentiation toward epithelial elements is very rare, and we illustrate a case of MPNST with glandular differentiation, comprising prominent well-formed glands, with a brief discussion of biphasic (spindle and glandular) neoplasms in the differential diagnosis. An index of suspicion for MPNST is necessary, due to the differing management from tumors in its differential diagnosis, and because of the potential for therapies toward molecular targets in future.en_US
dc.format.extent310 - 313en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectepithelialen_US
dc.subjectglandsen_US
dc.subjectglandular differentiationen_US
dc.subjectheterologous differentiationen_US
dc.subjectmalignant peripheral nerve sheath tumoren_US
dc.subjectsarcomaen_US
dc.subjectHumansen_US
dc.subjectNeoplasm Recurrence, Localen_US
dc.subjectNeurilemmomaen_US
dc.subjectSoft Tissue Neoplasmsen_US
dc.titleMalignant Peripheral Nerve Sheath Tumor With Divergent Glandular Differentiation.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1177/1066896917696749en_US
rioxxterms.licenseref.startdate2017-06en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfInt J Surg Patholen_US
pubs.issue4en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume25en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorThway, Khinen_US
dc.contributor.icrauthorMarsden,en_US


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